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Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths.
Cortés-López M, Chamely P, Hawkins AG, Stanley RF, Swett AD, Ganesan S, Mouhieddine TH, Dai X, Kluegel L, Chen C, Batta K, Furer N, Vedula RS, Beaulaurier J, Drong AW, Hickey S, Dusaj N, Mullokandov G, Stasiw AM, Su J, Chaligné R, Juul S, Harrington E, Knowles DA, Potenski CJ, Wiseman DH, Tanay A, Shlush L, Lindsley RC, Ghobrial IM, Taylor J, Abdel-Wahab O, Gaiti F, Landau DA. Cortés-López M, et al. Among authors: batta k. Cell Stem Cell. 2023 Sep 7;30(9):1262-1281.e8. doi: 10.1016/j.stem.2023.07.012. Epub 2023 Aug 14. Cell Stem Cell. 2023. PMID: 37582363
Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils.
Huerga Encabo H, Aramburu IV, Garcia-Albornoz M, Piganeau M, Wood H, Song A, Ferrelli A, Sharma A, Minutti CM, Domart MC, Papazoglou D, Gurashi K, Llorian Sopena M, Goldstone R, Fallesen T, Wang Q, Ariza-McNaughton L, Wiseman DH, Batta K, Gupta R, Papayannopoulos V, Bonnet D. Huerga Encabo H, et al. Among authors: batta k. Cell Stem Cell. 2023 Jun 1;30(6):781-799.e9. doi: 10.1016/j.stem.2023.05.004. Cell Stem Cell. 2023. PMID: 37267914 Free article.
The E592K variant of SF3B1 creates unique RNA missplicing and associates with high-risk MDS without ring sideroblasts.
Choi IY, Ling JP, Zhang J, Helmenstine E, Walter W, Tsakiroglou P, Bergman RE, Philippe C, Manley JL, Rouault-Pierre K, Li B, Wiseman DH, Batta K, Ouseph MM, Bernard E, Dubner B, Li X, Haferlach T, Koget A, Fazal S, Jain T, Gocke CD, DeZern AE, Dalton WB. Choi IY, et al. Among authors: batta k. Blood Adv. 2024 May 17:bloodadvances.2023011260. doi: 10.1182/bloodadvances.2023011260. Online ahead of print. Blood Adv. 2024. PMID: 38759096
Higher MDMX expression was associated with hypomethylating agent resistance and inferior survival in MDS patients, inferring it a potential therapeutic target.
Wang YH, Lin CC, Gurashi K, Wingelhofer B, Amaral FMR, Yao CY, Hsieh HT, Liu MC, Hou HA, Chou WC, Batta K, Wiseman DH, Tien HF. Wang YH, et al. Among authors: batta k. Leukemia. 2023 Dec;37(12):2507-2511. doi: 10.1038/s41375-023-02044-2. Epub 2023 Nov 2. Leukemia. 2023. PMID: 37919605 No abstract available.
Divergent clonal evolution of blastic plasmacytoid dendritic cell neoplasm and chronic myelomonocytic leukemia from a shared TET2-mutated origin.
Batta K, Bossenbroek HM, Pemmaraju N, Wilks DP, Chasty R, Dennis M, Milne P, Collin M, Beird HC, Taylor J, Patnaik MM, Cargo CA, Somervaille TCP, Wiseman DH. Batta K, et al. Leukemia. 2021 Nov;35(11):3299-3303. doi: 10.1038/s41375-021-01228-y. Epub 2021 Apr 8. Leukemia. 2021. PMID: 33833384 Free PMC article. No abstract available.
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