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Deep learning integrates histopathology and proteogenomics at a pan-cancer level.
Wang JM, Hong R, Demicco EG, Tan J, Lazcano R, Moreira AL, Li Y, Calinawan A, Razavian N, Schraink T, Gillette MA, Omenn GS, An E, Rodriguez H, Tsirigos A, Ruggles KV, Ding L, Robles AI, Mani DR, Rodland KD, Lazar AJ, Liu W, Fenyö D; Clinical Proteomic Tumor Analysis Consortium. Wang JM, et al. Among authors: tsirigos a. Cell Rep Med. 2023 Sep 19;4(9):101173. doi: 10.1016/j.xcrm.2023.101173. Epub 2023 Aug 14. Cell Rep Med. 2023. PMID: 37582371 Free PMC article.
KEAP1 mutation in lung adenocarcinoma promotes immune evasion and immunotherapy resistance.
Zavitsanou AM, Pillai R, Hao Y, Wu WL, Bartnicki E, Karakousi T, Rajalingam S, Herrera A, Karatza A, Rashidfarrokhi A, Solis S, Ciampricotti M, Yeaton AH, Ivanova E, Wohlhieter CA, Buus TB, Hayashi M, Karadal-Ferrena B, Pass HI, Poirier JT, Rudin CM, Wong KK, Moreira AL, Khanna KM, Tsirigos A, Papagiannakopoulos T, Koralov SB. Zavitsanou AM, et al. Among authors: tsirigos a. Cell Rep. 2023 Nov 28;42(11):113295. doi: 10.1016/j.celrep.2023.113295. Epub 2023 Oct 26. Cell Rep. 2023. PMID: 37889752 Free PMC article.
Machine learning approaches to predict drug efficacy and toxicity in oncology.
Badwan BA, Liaropoulos G, Kyrodimos E, Skaltsas D, Tsirigos A, Gorgoulis VG. Badwan BA, et al. Among authors: tsirigos a. Cell Rep Methods. 2023 Feb 21;3(2):100413. doi: 10.1016/j.crmeth.2023.100413. eCollection 2023 Feb 27. Cell Rep Methods. 2023. PMID: 36936080 Free PMC article. Review.
Digital spatial profiling to predict recurrence in grade 3 stage I lung adenocarcinoma.
Chang SH, Mezzano-Robinson V, Zhou H, Moreira A, Pillai R, Ramaswami S, Loomis C, Heguy A, Tsirigos A, Pass HI. Chang SH, et al. Among authors: tsirigos a. J Thorac Cardiovasc Surg. 2023 Oct 27:S0022-5223(23)01004-8. doi: 10.1016/j.jtcvs.2023.10.047. Online ahead of print. J Thorac Cardiovasc Surg. 2023. PMID: 37890657
Metabolic coordination between skin epithelium and type 17 immunity sustains chronic skin inflammation.
Subudhi I, Konieczny P, Prystupa A, Castillo RL, Sze-Tu E, Xing Y, Rosenblum D, Reznikov I, Sidhu I, Loomis C, Lu CP, Anandasabapathy N, Suárez-Fariñas M, Gudjonsson JE, Tsirigos A, Scher JU, Naik S. Subudhi I, et al. Among authors: tsirigos a. Immunity. 2024 May 14:S1074-7613(24)00227-9. doi: 10.1016/j.immuni.2024.04.022. Online ahead of print. Immunity. 2024. PMID: 38772365
Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation.
Tiniakou I, Hsu PF, Lopez-Zepeda LS, Garipler G, Esteva E, Adams NM, Jang G, Soni C, Lau CM, Liu F, Khodadadi-Jamayran A, Rodrick TC, Jones D, Tsirigos A, Ohler U, Bedford MT, Nimer SD, Kaartinen V, Mazzoni EO, Reizis B. Tiniakou I, et al. Among authors: tsirigos a. Sci Immunol. 2024 Apr 12;9(94):eadi1023. doi: 10.1126/sciimmunol.adi1023. Epub 2024 Apr 12. Sci Immunol. 2024. PMID: 38608038
Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer.
Pillai R, LeBoeuf SE, Hao Y, New C, Blum JLE, Rashidfarrokhi A, Huang SM, Bahamon C, Wu WL, Karadal-Ferrena B, Herrera A, Ivanova E, Cross M, Bossowski JP, Ding H, Hayashi M, Rajalingam S, Karakousi T, Sayin VI, Khanna KM, Wong KK, Wild R, Tsirigos A, Poirier JT, Rudin CM, Davidson SM, Koralov SB, Papagiannakopoulos T. Pillai R, et al. Among authors: tsirigos a. Sci Adv. 2024 Mar 29;10(13):eadm9859. doi: 10.1126/sciadv.adm9859. Epub 2024 Mar 27. Sci Adv. 2024. PMID: 38536921 Free PMC article.
Self-supervised artificial intelligence predicts recurrence, metastasis and disease specific death from primary cutaneous squamous cell carcinoma at diagnosis.
Coudray N, Juarez MC, Criscito MC, Quiros AC, Wilken R, Cullison SRJ, Stevenson ML, Doudican NA, Yuan K, Aquino JD, Klufas DM, North JP, Yu SS, Murad F, Ruiz E, Schmults CD, Tsirigos A, Carucci JA. Coudray N, et al. Among authors: tsirigos a. Res Sq [Preprint]. 2023 Dec 13:rs.3.rs-3607399. doi: 10.21203/rs.3.rs-3607399/v1. Res Sq. 2023. PMID: 38168253 Free PMC article. Preprint.
3D Enhancer-promoter networks provide predictive features for gene expression and coregulation in early embryonic lineages.
Murphy D, Salataj E, Di Giammartino DC, Rodriguez-Hernaez J, Kloetgen A, Garg V, Char E, Uyehara CM, Ee LS, Lee U, Stadtfeld M, Hadjantonakis AK, Tsirigos A, Polyzos A, Apostolou E. Murphy D, et al. Among authors: tsirigos a. Nat Struct Mol Biol. 2024 Jan;31(1):125-140. doi: 10.1038/s41594-023-01130-4. Epub 2023 Dec 5. Nat Struct Mol Biol. 2024. PMID: 38053013
175 results