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Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing.
Nat Commun. 2024 Mar 2;15(1):1931. doi: 10.1038/s41467-024-46114-0.
Nat Commun. 2024.
PMID: 38431691
Free PMC article.
Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells.
Rattigan KM, Brabcova Z, Sarnello D, Zarou MM, Roy K, Kwan R, de Beauchamp L, Dawson A, Ianniciello A, Khalaf A, Kalkman ER, Scott MT, Dunn K, Sumpton D, Michie AM, Copland M, Tardito S, Gottlieb E, Vignir Helgason G.
Rattigan KM, et al. Among authors: sarnello d.
Nat Commun. 2023 Aug 17;14(1):4634. doi: 10.1038/s41467-023-40222-z.
Nat Commun. 2023.
PMID: 37591854
Free PMC article.
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Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells.
Rattigan KM, Zarou MM, Brabcova Z, Prasad B, Zerbst D, Sarnello D, Kalkman ER, Ianniciello A, Scott MT, Dunn K, Shokry E, Sumpton D, Copland M, Tardito S, Vande Voorde J, Mussai F, Cheng P, Helgason GV.
Rattigan KM, et al. Among authors: sarnello d.
EMBO Rep. 2023 Oct 9;24(10):e56279. doi: 10.15252/embr.202256279. Epub 2023 Jul 25.
EMBO Rep. 2023.
PMID: 37489735
Free PMC article.
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Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth.
Wiche Salinas TR, Zhang Y, Sarnello D, Zhyvoloup A, Marchand LR, Fert A, Planas D, Lodha M, Chatterjee D, Karwacz K, Oxenford S, Routy JP, Irlbeck D, Amrine-Madsen H, Ancuta P, Fassati A.
Wiche Salinas TR, et al. Among authors: sarnello d.
Proc Natl Acad Sci U S A. 2021 Nov 30;118(48):e2105927118. doi: 10.1073/pnas.2105927118.
Proc Natl Acad Sci U S A. 2021.
PMID: 34819367
Free PMC article.
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