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An antibiotic from an uncultured bacterium binds to an immutable target.
Shukla R, Peoples AJ, Ludwig KC, Maity S, Derks MGN, De Benedetti S, Krueger AM, Vermeulen BJA, Harbig T, Lavore F, Kumar R, Honorato RV, Grein F, Nieselt K, Liu Y, Bonvin AMJJ, Baldus M, Kubitscheck U, Breukink E, Achorn C, Nitti A, Schwalen CJ, Spoering AL, Ling LL, Hughes D, Lelli M, Roos WH, Lewis K, Schneider T, Weingarth M. Shukla R, et al. Among authors: breukink e. Cell. 2023 Sep 14;186(19):4059-4073.e27. doi: 10.1016/j.cell.2023.07.038. Epub 2023 Aug 22. Cell. 2023. PMID: 37611581 Free article.
A new antibiotic from an uncultured bacterium binds to an immutable target.
Shukla R, Peoples AJ, Ludwig KC, Maity S, Derks MGN, de Benedetti S, Krueger AM, Vermeulen BJA, Lavore F, Honorato RV, Grein F, Bonvin A, Kubitscheck U, Breukink E, Achorn C, Nitti A, Schwalen CJ, Spoering AL, Ling LL, Hughes D, Lelli M, Roos WH, Lewis K, Schneider T, Weingarth M. Shukla R, et al. Among authors: breukink e. bioRxiv [Preprint]. 2023 May 15:2023.05.15.540765. doi: 10.1101/2023.05.15.540765. bioRxiv. 2023. PMID: 37292624 Free PMC article. Updated. Preprint.
The enigmatic mode of action of the lantibiotic epilancin 15X.
Wang X, Xu Y, Martin NI, Breukink E. Wang X, et al. Among authors: breukink e. Biochim Biophys Acta Biomembr. 2024 Mar;1866(3):184282. doi: 10.1016/j.bbamem.2024.184282. Epub 2024 Jan 12. Biochim Biophys Acta Biomembr. 2024. PMID: 38218577 Free article. Review.
Development of teixobactin analogues containing hydrophobic, non-proteogenic amino acids that are highly potent against multidrug-resistant bacteria and biofilms.
Parmar A, Lakshminarayanan R, Iyer A, Goh ETL, To TY, Yam JKH, Yang L, Newire E, Robertson MC, Prior SH, Breukink E, Madder A, Singh I. Parmar A, et al. Among authors: breukink e. Eur J Med Chem. 2023 Dec 5;261:115853. doi: 10.1016/j.ejmech.2023.115853. Epub 2023 Oct 7. Eur J Med Chem. 2023. PMID: 37857144
Host defence peptide plectasin targets bacterial cell wall precursor lipid II by a calcium-sensitive supramolecular mechanism.
Jekhmane S, Derks MGN, Maity S, Slingerland CJ, Tehrani KHME, Medeiros-Silva J, Charitou V, Ammerlaan D, Fetz C, Consoli NA, Cochrane RVK, Matheson EJ, van der Weijde M, Elenbaas BOW, Lavore F, Cox R, Lorent JH, Baldus M, Künzler M, Lelli M, Cochrane SA, Martin NI, Roos WH, Breukink E, Weingarth M. Jekhmane S, et al. Among authors: breukink e. Nat Microbiol. 2024 May 23. doi: 10.1038/s41564-024-01696-9. Online ahead of print. Nat Microbiol. 2024. PMID: 38783023
Specific Lipid Studies in Complex Membranes by Solid-State NMR Spectroscopy.
van Beekveld RAM, Derks MGN, Kumar R, Smid L, Maass T, Medeiros-Silva J, Breukink E, Weingarth M. van Beekveld RAM, et al. Among authors: breukink e. Chemistry. 2022 Dec 15;28(70):e202202472. doi: 10.1002/chem.202202472. Epub 2022 Oct 25. Chemistry. 2022. PMID: 36098094 Free PMC article.
156 results