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A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation.
Ralvenius WT, Mungenast AE, Woolf H, Huston MM, Gillingham TZ, Godin SK, Penney J, Cam HP, Gao F, Fernandez CG, Czako B, Lightfoot Y, Ray WJ, Beckmann A, Goate AM, Marcora E, Romero-Molina C, Ayata P, Schaefer A, Gjoneska E, Tsai LH. Ralvenius WT, et al. Among authors: schaefer a. J Exp Med. 2023 Nov 6;220(11):e20222105. doi: 10.1084/jem.20222105. Epub 2023 Aug 29. J Exp Med. 2023. PMID: 37642942 Free PMC article.
Autism-like syndrome is induced by pharmacological suppression of BET proteins in young mice.
Sullivan JM, Badimon A, Schaefer U, Ayata P, Gray J, Chung CW, von Schimmelmann M, Zhang F, Garton N, Smithers N, Lewis H, Tarakhovsky A, Prinjha RK, Schaefer A. Sullivan JM, et al. Among authors: schaefer a, schaefer u. J Exp Med. 2015 Oct 19;212(11):1771-81. doi: 10.1084/jem.20151271. Epub 2015 Sep 21. J Exp Med. 2015. PMID: 26392221 Free PMC article.
CSF-1 controls cerebellar microglia and is required for motor function and social interaction.
Kana V, Desland FA, Casanova-Acebes M, Ayata P, Badimon A, Nabel E, Yamamuro K, Sneeboer M, Tan IL, Flanigan ME, Rose SA, Chang C, Leader A, Le Bourhis H, Sweet ES, Tung N, Wroblewska A, Lavin Y, See P, Baccarini A, Ginhoux F, Chitu V, Stanley ER, Russo SJ, Yue Z, Brown BD, Joyner AL, De Witte LD, Morishita H, Schaefer A, Merad M. Kana V, et al. Among authors: schaefer a. J Exp Med. 2019 Oct 7;216(10):2265-2281. doi: 10.1084/jem.20182037. Epub 2019 Jul 26. J Exp Med. 2019. PMID: 31350310 Free PMC article.
Epigenetic regulation of brain region-specific microglia clearance activity.
Ayata P, Badimon A, Strasburger HJ, Duff MK, Montgomery SE, Loh YE, Ebert A, Pimenova AA, Ramirez BR, Chan AT, Sullivan JM, Purushothaman I, Scarpa JR, Goate AM, Busslinger M, Shen L, Losic B, Schaefer A. Ayata P, et al. Among authors: schaefer a. Nat Neurosci. 2018 Aug;21(8):1049-1060. doi: 10.1038/s41593-018-0192-3. Epub 2018 Jul 23. Nat Neurosci. 2018. PMID: 30038282 Free PMC article.
Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling.
Gunner G, Cheadle L, Johnson KM, Ayata P, Badimon A, Mondo E, Nagy MA, Liu L, Bemiller SM, Kim KW, Lira SA, Lamb BT, Tapper AR, Ransohoff RM, Greenberg ME, Schaefer A, Schafer DP. Gunner G, et al. Among authors: schaefer a. Nat Neurosci. 2019 Jul;22(7):1075-1088. doi: 10.1038/s41593-019-0419-y. Epub 2019 Jun 17. Nat Neurosci. 2019. PMID: 31209379 Free PMC article.
Negative feedback control of neuronal activity by microglia.
Badimon A, Strasburger HJ, Ayata P, Chen X, Nair A, Ikegami A, Hwang P, Chan AT, Graves SM, Uweru JO, Ledderose C, Kutlu MG, Wheeler MA, Kahan A, Ishikawa M, Wang YC, Loh YE, Jiang JX, Surmeier DJ, Robson SC, Junger WG, Sebra R, Calipari ES, Kenny PJ, Eyo UB, Colonna M, Quintana FJ, Wake H, Gradinaru V, Schaefer A. Badimon A, et al. Among authors: schaefer a. Nature. 2020 Oct;586(7829):417-423. doi: 10.1038/s41586-020-2777-8. Epub 2020 Sep 30. Nature. 2020. PMID: 32999463 Free PMC article.
Cerebellar neurodegeneration in the absence of microRNAs.
Schaefer A, O'Carroll D, Tan CL, Hillman D, Sugimori M, Llinas R, Greengard P. Schaefer A, et al. J Exp Med. 2007 Jul 9;204(7):1553-8. doi: 10.1084/jem.20070823. Epub 2007 Jul 2. J Exp Med. 2007. PMID: 17606634 Free PMC article.
1,250 results