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A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation.
Ralvenius WT, Mungenast AE, Woolf H, Huston MM, Gillingham TZ, Godin SK, Penney J, Cam HP, Gao F, Fernandez CG, Czako B, Lightfoot Y, Ray WJ, Beckmann A, Goate AM, Marcora E, Romero-Molina C, Ayata P, Schaefer A, Gjoneska E, Tsai LH. Ralvenius WT, et al. Among authors: tsai lh. J Exp Med. 2023 Nov 6;220(11):e20222105. doi: 10.1084/jem.20222105. Epub 2023 Aug 29. J Exp Med. 2023. PMID: 37642942 Free PMC article.
Targeting the correct HDAC(s) to treat cognitive disorders.
Fischer A, Sananbenesi F, Mungenast A, Tsai LH. Fischer A, et al. Among authors: tsai lh. Trends Pharmacol Sci. 2010 Dec;31(12):605-17. doi: 10.1016/j.tips.2010.09.003. Epub 2010 Oct 25. Trends Pharmacol Sci. 2010. PMID: 20980063 Review.
Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.
Chung CY, Khurana V, Auluck PK, Tardiff DF, Mazzulli JR, Soldner F, Baru V, Lou Y, Freyzon Y, Cho S, Mungenast AE, Muffat J, Mitalipova M, Pluth MD, Jui NT, Schüle B, Lippard SJ, Tsai LH, Krainc D, Buchwald SL, Jaenisch R, Lindquist S. Chung CY, et al. Among authors: tsai lh. Science. 2013 Nov 22;342(6161):983-7. doi: 10.1126/science.1245296. Epub 2013 Oct 24. Science. 2013. PMID: 24158904 Free PMC article.
Histone deacetylases in memory and cognition.
Penney J, Tsai LH. Penney J, et al. Among authors: tsai lh. Sci Signal. 2014 Dec 9;7(355):re12. doi: 10.1126/scisignal.aaa0069. Sci Signal. 2014. PMID: 25492968 Review.
Basolateral amygdala bidirectionally modulates stress-induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway.
Rei D, Mason X, Seo J, Gräff J, Rudenko A, Wang J, Rueda R, Siegert S, Cho S, Canter RG, Mungenast AE, Deisseroth K, Tsai LH. Rei D, et al. Among authors: tsai lh. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7291-6. doi: 10.1073/pnas.1415845112. Epub 2015 May 20. Proc Natl Acad Sci U S A. 2015. PMID: 25995364 Free PMC article.
The schizophrenia risk gene product miR-137 alters presynaptic plasticity.
Siegert S, Seo J, Kwon EJ, Rudenko A, Cho S, Wang W, Flood Z, Martorell AJ, Ericsson M, Mungenast AE, Tsai LH. Siegert S, et al. Among authors: tsai lh. Nat Neurosci. 2015 Jul;18(7):1008-16. doi: 10.1038/nn.4023. Epub 2015 May 25. Nat Neurosci. 2015. PMID: 26005852 Free PMC article.
411 results