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176 results

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Page 1
Progressive plasticity during colorectal cancer metastasis.
Moorman AR, Cambuli F, Benitez EK, Jiang Q, Xie Y, Mahmoud A, Lumish M, Hartner S, Balkaran S, Bermeo J, Asawa S, Firat C, Saxena A, Luthra A, Sgambati V, Luckett K, Wu F, Li Y, Yi Z, Masilionis I, Soares K, Pappou E, Yaeger R, Kingham P, Jarnagin W, Paty P, Weiser MR, Mazutis L, D'Angelica M, Shia J, Garcia-Aguilar J, Nawy T, Hollmann TJ, Chaligné R, Sanchez-Vega F, Sharma R, Pe'er D, Ganesh K. Moorman AR, et al. Among authors: yaeger r. bioRxiv [Preprint]. 2023 Aug 21:2023.08.18.553925. doi: 10.1101/2023.08.18.553925. bioRxiv. 2023. PMID: 37662289 Free PMC article. Preprint.
Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma.
Li Z, Zhuang X, Pan CH, Yan Y, Thummalapalli R, Hallin J, Torborg S, Singhal A, Chang JC, Manchado E, Dow LE, Yaeger R, Christensen JG, Lowe SW, Rudin CM, Joost S, Tammela T. Li Z, et al. Among authors: yaeger r. bioRxiv [Preprint]. 2023 Oct 1:2023.09.29.560194. doi: 10.1101/2023.09.29.560194. bioRxiv. 2023. PMID: 37808711 Free PMC article. Updated. Preprint.
Tumorigenesis driven by the BRAFV600E oncoprotein requires secondary mutations that overcome its feedback inhibition of migration and invasion.
Gadal S, Boyer JA, Roy SF, Outmezguine NA, Sharma M, Li H, Fan N, Chan E, Romin Y, Barlas A, Chang Q, Pancholi P, Timaul NM, Overholtzer M, Yaeger R, Manova-Todorova K, de Stanchina E, Bosenberg M, Rosen N. Gadal S, et al. Among authors: yaeger r. bioRxiv [Preprint]. 2024 Apr 20:2023.11.21.568071. doi: 10.1101/2023.11.21.568071. bioRxiv. 2024. PMID: 38659913 Free PMC article. Preprint.
Immune checkpoint inhibitors for POLE or POLD1 proofreading-deficient metastatic colorectal cancer.
Ambrosini M, Rousseau B, Manca P, Artz O, Marabelle A, André T, Maddalena G, Mazzoli G, Intini R, Cohen R, Cercek A, Segal NH, Saltz L, Varghese AM, Yaeger R, Nusrat M, Goldberg Z, Ku GY, El Dika I, Margalit O, Grinshpun A, Kasi P, Schilsky R, Lutfi A, Shacham-Shmueli E, Khan Afghan M, Weiss L, Westphalen CB, Conca V, Decker B, Randon G, Elez E, Fakih M, Schrock AB, Cremolini C, Jayachandran P, Overman MJ, Lonardi S, Pietrantonio F. Ambrosini M, et al. Among authors: yaeger r. Ann Oncol. 2024 May 3:S0923-7534(24)00104-2. doi: 10.1016/j.annonc.2024.03.009. Online ahead of print. Ann Oncol. 2024. PMID: 38777726
Early-Onset Colorectal Cancer Patients Do Not Require Shorter Intervals for Post-Surgical Surveillance Colonoscopy.
Mendelsohn RB, Hahn AI, Palmaira RL, Saxena AR, Mukthinuthalapati PK, Schattner MA, Markowitz AJ, Ludwig E, Shah P, Calo D, Gerdes H, Yaeger R, Stadler Z, Zauber AG, Cercek A. Mendelsohn RB, et al. Among authors: yaeger r. Clin Gastroenterol Hepatol. 2024 May 8:S1542-3565(24)00436-1. doi: 10.1016/j.cgh.2024.04.029. Online ahead of print. Clin Gastroenterol Hepatol. 2024. PMID: 38729386
Precision medicine for pancreatic cancer: Characterizing the clinico-genomic landscape and outcomes of KRAS G12C-mutated disease.
Keane F, Chou JF, Walch H, Schoenfeld J, Singhal A, Cowzer D, Harrold E, O'Connor C, Park W, Varghese A, El Dika I, Balogun F, Yu KH, Capanu M, Schultz N, Yaeger R, O'Reilly EM. Keane F, et al. Among authors: yaeger r. J Natl Cancer Inst. 2024 May 3:djae095. doi: 10.1093/jnci/djae095. Online ahead of print. J Natl Cancer Inst. 2024. PMID: 38702822
A next-generation BRAF inhibitor overcomes resistance to BRAF inhibition in patients with BRAF-mutant cancers using pharmacokinetics-informed dose escalation.
Yaeger R, McKean MA, Haq R, Beck JT, Taylor MH, Cohen JE, Bowles DW, Gadgeel SM, Mihalcioiu C, Papadopoulos KP, Diamond EL, Sturtz KB, Feng G, Drescher SK, Reddy MB, Sengupta B, Maity AK, Brown SA, Singh A, Brown EN, Baer BR, Wong J, Mou TC, Wu WI, Kahn DR, Gadal S, Rosen N, Gaudino JJ, Lee PA, Hartley DP, Rothenberg SM. Yaeger R, et al. Cancer Discov. 2024 Apr 30. doi: 10.1158/2159-8290.CD-24-0024. Online ahead of print. Cancer Discov. 2024. PMID: 38691346
Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer.
Yaeger R, Uboha NV, Pelster MS, Bekaii-Saab TS, Barve M, Saltzman J, Sabari JK, Peguero JA, Paulson AS, Jänne PA, Cruz-Correa M, Anderes K, Velastegui K, Yan X, Der-Torossian H, Klempner SJ, Kopetz SE. Yaeger R, et al. Cancer Discov. 2024 Apr 8:OF1-OF12. doi: 10.1158/2159-8290.CD-24-0217. Online ahead of print. Cancer Discov. 2024. PMID: 38587856
Molecular and Clinical Determinants of Acquired Resistance and Treatment Duration for Targeted Therapies in Colorectal Cancer.
Harrold E, Keane F, Walch H, Chou JF, Sinopoli J, Palladino S, Al-Rawi DH, Chadalavada K, Manca P, Chalasani S, Yang J, Cercek A, Shia J, Capanu M, Bakhoum SF, Schultz N, Chatila WK, Yaeger R. Harrold E, et al. Among authors: yaeger r. Clin Cancer Res. 2024 Mar 19. doi: 10.1158/1078-0432.CCR-23-4005. Online ahead of print. Clin Cancer Res. 2024. PMID: 38502113
Alliance for clinical trials in Oncology (Alliance) trial A022101/NRG-GI009: a pragmatic randomized phase III trial evaluating total ablative therapy for patients with limited metastatic colorectal cancer: evaluating radiation, ablation, and surgery (ERASur).
Hitchcock KE, Miller ED, Shi Q, Dixon JG, Gholami S, White SB, Wu C, Goulet CC, George M, Jee KW, Wright CL, Yaeger R, Shergill A, Hong TS, George TJ, O'Reilly EM, Meyerhardt JA, Romesser PB. Hitchcock KE, et al. Among authors: yaeger r. BMC Cancer. 2024 Feb 13;24(1):201. doi: 10.1186/s12885-024-11899-2. BMC Cancer. 2024. PMID: 38350888 Free PMC article. Clinical Trial.
176 results