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Design principles for cyclin K molecular glue degraders.
Kozicka Z, Suchyta DJ, Focht V, Kempf G, Petzold G, Jentzsch M, Zou C, Di Genua C, Donovan KA, Coomar S, Cigler M, Mayor-Ruiz C, Schmid-Burgk JL, Häussinger D, Winter GE, Fischer ES, Słabicki M, Gillingham D, Ebert BL, Thomä NH. Kozicka Z, et al. Among authors: gillingham d. Nat Chem Biol. 2024 Jan;20(1):93-102. doi: 10.1038/s41589-023-01409-z. Epub 2023 Sep 7. Nat Chem Biol. 2024. PMID: 37679459 Free PMC article.
An artificial metalloenzyme for olefin metathesis.
Mayer C, Gillingham DG, Ward TR, Hilvert D. Mayer C, et al. Among authors: gillingham dg. Chem Commun (Camb). 2011 Nov 28;47(44):12068-70. doi: 10.1039/c1cc15005g. Epub 2011 Oct 12. Chem Commun (Camb). 2011. PMID: 21991583
De novo chemoenzymatic synthesis of sialic acid.
Stallforth P, Matthies S, Adibekian A, Gillingham DG, Hilvert D, Seeberger PH. Stallforth P, et al. Among authors: gillingham dg. Chem Commun (Camb). 2012 Dec 21;48(98):11987-9. doi: 10.1039/c2cc37305j. Chem Commun (Camb). 2012. PMID: 23128386
Structure-selective catalytic alkylation of DNA and RNA.
Tishinov K, Schmidt K, Häussinger D, Gillingham DG. Tishinov K, et al. Among authors: gillingham dg. Angew Chem Int Ed Engl. 2012 Nov 26;51(48):12000-4. doi: 10.1002/anie.201205201. Epub 2012 Oct 22. Angew Chem Int Ed Engl. 2012. PMID: 23090851 No abstract available.
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K.
Słabicki M, Kozicka Z, Petzold G, Li YD, Manojkumar M, Bunker RD, Donovan KA, Sievers QL, Koeppel J, Suchyta D, Sperling AS, Fink EC, Gasser JA, Wang LR, Corsello SM, Sellar RS, Jan M, Gillingham D, Scholl C, Fröhling S, Golub TR, Fischer ES, Thomä NH, Ebert BL. Słabicki M, et al. Among authors: gillingham d. Nature. 2020 Sep;585(7824):293-297. doi: 10.1038/s41586-020-2374-x. Epub 2020 Jun 3. Nature. 2020. PMID: 32494016 Free PMC article.
47 results