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Activation of the transcription factor NFAT5 in the tumor microenvironment enforces CD8+ T cell exhaustion.
Tillé L, Cropp D, Charmoy M, Reichenbach P, Andreatta M, Wyss T, Bodley G, Crespo I, Nassiri S, Lourenco J, Leblond MM, Lopez-Rodriguez C, Speiser DE, Coukos G, Irving M, Carmona SJ, Held W, Verdeil G. Tillé L, et al. Among authors: irving m. Nat Immunol. 2023 Oct;24(10):1645-1653. doi: 10.1038/s41590-023-01614-x. Epub 2023 Sep 14. Nat Immunol. 2023. PMID: 37709986
Orthogonal cytokine engineering enables novel synthetic effector states escaping canonical exhaustion in tumor-rejecting CD8+ T cells.
Corria-Osorio J, Carmona SJ, Stefanidis E, Andreatta M, Ortiz-Miranda Y, Muller T, Rota IA, Crespo I, Seijo B, Castro W, Jimenez-Luna C, Scarpellino L, Ronet C, Spill A, Lanitis E, Romero P, Luther SA, Irving M, Coukos G. Corria-Osorio J, et al. Among authors: irving m. Nat Immunol. 2023 May;24(5):869-883. doi: 10.1038/s41590-023-01477-2. Epub 2023 Apr 20. Nat Immunol. 2023. PMID: 37081150 Free PMC article.
Targeting the tumor vasculature to enhance T cell activity.
Lanitis E, Irving M, Coukos G. Lanitis E, et al. Among authors: irving m. Curr Opin Immunol. 2015 Apr;33:55-63. doi: 10.1016/j.coi.2015.01.011. Epub 2015 Feb 6. Curr Opin Immunol. 2015. PMID: 25665467 Free PMC article. Review.
IL-2 engineered MSCs rescue T cells in tumours.
Irving M, Ortiz-Miranda Y, Coukos G. Irving M, et al. Nat Cell Biol. 2022 Dec;24(12):1689-1691. doi: 10.1038/s41556-022-01029-0. Nat Cell Biol. 2022. PMID: 36474071 No abstract available.
Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors.
Schmidt J, Chiffelle J, Perez MAS, Magnin M, Bobisse S, Arnaud M, Genolet R, Cesbron J, Barras D, Navarro Rodrigo B, Benedetti F, Michel A, Queiroz L, Baumgaertner P, Guillaume P, Hebeisen M, Michielin O, Nguyen-Ngoc T, Huber F, Irving M, Tissot-Renaud S, Stevenson BJ, Rusakiewicz S, Dangaj Laniti D, Bassani-Sternberg M, Rufer N, Gfeller D, Kandalaft LE, Speiser DE, Zoete V, Coukos G, Harari A. Schmidt J, et al. Among authors: irving m. Nat Commun. 2023 Jun 6;14(1):3188. doi: 10.1038/s41467-023-38946-z. Nat Commun. 2023. PMID: 37280206 Free PMC article.
Sensitive identification of neoantigens and cognate TCRs in human solid tumors.
Arnaud M, Chiffelle J, Genolet R, Navarro Rodrigo B, Perez MAS, Huber F, Magnin M, Nguyen-Ngoc T, Guillaume P, Baumgaertner P, Chong C, Stevenson BJ, Gfeller D, Irving M, Speiser DE, Schmidt J, Zoete V, Kandalaft LE, Bassani-Sternberg M, Bobisse S, Coukos G, Harari A. Arnaud M, et al. Among authors: irving m. Nat Biotechnol. 2022 May;40(5):656-660. doi: 10.1038/s41587-021-01072-6. Epub 2021 Nov 15. Nat Biotechnol. 2022. PMID: 34782741 Free PMC article.
A lentiviral vector for the production of T cells with an inducible transgene and a constitutively expressed tumour-targeting receptor.
Reichenbach P, Giordano Attianese GMP, Ouchen K, Cribioli E, Triboulet M, Ash S, Saillard M, Vuillefroy de Silly R, Coukos G, Irving M. Reichenbach P, et al. Among authors: irving m. Nat Biomed Eng. 2023 Sep;7(9):1063-1080. doi: 10.1038/s41551-023-01013-5. Epub 2023 Apr 17. Nat Biomed Eng. 2023. PMID: 37069267 Free PMC article.
A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy.
Giordano-Attianese G, Gainza P, Gray-Gaillard E, Cribioli E, Shui S, Kim S, Kwak MJ, Vollers S, Corria Osorio AJ, Reichenbach P, Bonet J, Oh BH, Irving M, Coukos G, Correia BE. Giordano-Attianese G, et al. Among authors: irving m. Nat Biotechnol. 2020 Apr;38(4):426-432. doi: 10.1038/s41587-019-0403-9. Epub 2020 Feb 3. Nat Biotechnol. 2020. PMID: 32015549
660 results