Staker BL - Search Results

1

Identification of and Structural Insights into Hit Compounds Targeting N-Myristoyltransferase for Cryptosporidium Drug Development.

Fenwick MK, Reers AR, Liu Y, Zigweid R, Sankaran B, Shin J, Hulverson MA, Hammerson B, Fernández Álvaro E, Myler PJ, Kaushansky A, Van Voorhis WC, Fan E, Staker BL. Fenwick MK, et al. Among authors: staker bl. ACS Infect Dis. 2023 Oct 13;9(10):1821-1833. doi: 10.1021/acsinfecdis.3c00151. Epub 2023 Sep 18. ACS Infect Dis. 2023. PMID: 37722671 Free PMC article.

2

Multi-target parallel processing approach for gene-to-structure determination of the influenza polymerase PB2 subunit.

Armour BL, Barnes SR, Moen SO, Smith E, Raymond AC, Fairman JW, Stewart LJ, Staker BL, Begley DW, Edwards TE, Lorimer DD. Armour BL, et al. Among authors: staker bl. J Vis Exp. 2013 Jun 28;(76):4225. doi: 10.3791/4225. J Vis Exp. 2013. PMID: 23851357 Free PMC article.

3

Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors.

Ameriks MK, Bembenek SD, Burdett MT, Choong IC, Edwards JP, Gebauer D, Gu Y, Karlsson L, Purkey HE, Staker BL, Sun S, Thurmond RL, Zhu J. Ameriks MK, et al. Among authors: staker bl. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4060-4. doi: 10.1016/j.bmcl.2010.05.086. Epub 2010 May 25. Bioorg Med Chem Lett. 2010. PMID: 20541404

4

Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis.

Ioanoviciu A, Antony S, Pommier Y, Staker BL, Stewart L, Cushman M. Ioanoviciu A, et al. Among authors: staker bl. J Med Chem. 2005 Jul 28;48(15):4803-14. doi: 10.1021/jm050076b. J Med Chem. 2005. PMID: 16033260

5

ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.

Towler P, Staker B, Prasad SG, Menon S, Tang J, Parsons T, Ryan D, Fisher M, Williams D, Dales NA, Patane MA, Pantoliano MW. Towler P, et al. J Biol Chem. 2004 Apr 23;279(17):17996-8007. doi: 10.1074/jbc.M311191200. Epub 2004 Jan 30. J Biol Chem. 2004. PMID: 14754895 Free PMC article.

6

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.

Burgin AB, Magnusson OT, Singh J, Witte P, Staker BL, Bjornsson JM, Thorsteinsdottir M, Hrafnsdottir S, Hagen T, Kiselyov AS, Stewart LJ, Gurney ME. Burgin AB, et al. Among authors: staker bl. Nat Biotechnol. 2010 Jan;28(1):63-70. doi: 10.1038/nbt.1598. Epub 2009 Dec 27. Nat Biotechnol. 2010. PMID: 20037581

7

The plug-based nanovolume Microcapillary Protein Crystallization System (MPCS).

Gerdts CJ, Elliott M, Lovell S, Mixon MB, Napuli AJ, Staker BL, Nollert P, Stewart L. Gerdts CJ, et al. Among authors: staker bl. Acta Crystallogr D Biol Crystallogr. 2008 Nov;64(Pt 11):1116-22. doi: 10.1107/S0907444908028060. Epub 2008 Oct 18. Acta Crystallogr D Biol Crystallogr. 2008. PMID: 19020349 Free PMC article.

8

Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids.

Fox BM, Xiao X, Antony S, Kohlhagen G, Pommier Y, Staker BL, Stewart L, Cushman M. Fox BM, et al. Among authors: staker bl. J Med Chem. 2003 Jul 17;46(15):3275-82. doi: 10.1021/jm0300476. J Med Chem. 2003. PMID: 12852757

9

Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1).

Raymond AC, Staker BL, Burgin AB Jr. Raymond AC, et al. Among authors: staker bl. J Biol Chem. 2005 Jun 10;280(23):22029-35. doi: 10.1074/jbc.M502148200. Epub 2005 Apr 4. J Biol Chem. 2005. PMID: 15811850 Free article.

10

Structure of Hsp15 reveals a novel RNA-binding motif.

Staker BL, Korber P, Bardwell JC, Saper MA. Staker BL, et al. EMBO J. 2000 Feb 15;19(4):749-57. doi: 10.1093/emboj/19.4.749. EMBO J. 2000. PMID: 10675344 Free PMC article.

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