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Page 1
Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection.
Baldeon Vaca G, Meyer M, Cadete A, Hsiao CJ, Golding A, Jeon A, Jacquinet E, Azcue E, Guan CM, Sanchez-Felix X, Pietzsch CA, Mire CE, Hyde MA, Comeaux ME, Williams JM, Sung JC, Carfi A, Edwards DK, Bukreyev A, Bahl K. Baldeon Vaca G, et al. Among authors: carfi a. Sci Adv. 2023 Sep 22;9(38):eadh1655. doi: 10.1126/sciadv.adh1655. Epub 2023 Sep 22. Sci Adv. 2023. PMID: 37738334 Free PMC article.
Altering the mRNA-1273 dosing interval impacts the kinetics, quality, and magnitude of immune responses in mice.
Garcia-Dominguez D, Henry C, Ma L, Jani H, Amato NJ, Manning T, Freyn A, Davis H, Hsiao CJ, Li M, Koch H, Elbashir S, DiPiazza A, Carfi A, Edwards D, Bahl K. Garcia-Dominguez D, et al. Among authors: carfi a. Front Immunol. 2022 Nov 8;13:948335. doi: 10.3389/fimmu.2022.948335. eCollection 2022. Front Immunol. 2022. PMID: 36426367 Free PMC article.
Infant rhesus macaques immunized against SARS-CoV-2 are protected against heterologous virus challenge 1 year later.
Milligan EC, Olstad K, Williams CA, Mallory M, Cano P, Cross KA, Munt JE, Garrido C, Lindesmith L, Watanabe J, Usachenko JL, Hopkins L, Immareddy R, Shaan Lakshmanappa Y, Elizaldi SR, Roh JW, Sammak RL, Pollard RE, Yee JL, Herbek S, Scobey T, Miehlke D, Fouda G, Ferrari G, Gao H, Shen X, Kozlowski PA, Montefiori D, Hudgens MG, Edwards DK, Carfi A, Corbett KS, Graham BS, Fox CB, Tomai M, Iyer SS, Baric R, Reader R, Dittmer DP, Van Rompay KKA, Permar SR, De Paris K. Milligan EC, et al. Among authors: carfi a. Sci Transl Med. 2023 Mar;15(685):eadd6383. doi: 10.1126/scitranslmed.add6383. Epub 2023 Mar 1. Sci Transl Med. 2023. PMID: 36454813 Free PMC article.
Increased neutralization potency and breadth elicited by a SARS-CoV-2 mRNA vaccine forming virus-like particles.
Zhang P, Falcone S, Tsybovsky Y, Singh M, Gopan V, Miao H, Seo Y, Rogers D, Renzi I, Lai YT, Narayanan E, Stewart-Jones G, Himansu S, Carfi A, Fauci AS, Lusso P. Zhang P, et al. Among authors: carfi a. Proc Natl Acad Sci U S A. 2023 Jul 18;120(29):e2305896120. doi: 10.1073/pnas.2305896120. Epub 2023 Jul 10. Proc Natl Acad Sci U S A. 2023. PMID: 37428933 Free PMC article.
Domain-based mRNA vaccines encoding spike protein N-terminal and receptor binding domains confer protection against SARS-CoV-2.
Stewart-Jones GBE, Elbashir SM, Wu K, Lee D, Renzi I, Ying B, Koch M, Sein CE, Choi A, Whitener B, Garcia-Dominguez D, Henry C, Woods A, Ma L, Montes Berrueta D, Avena LE, Quinones J, Falcone S, Hsiao CJ, Scheaffer SM, Thackray LB, White P, Diamond MS, Edwards DK, Carfi A. Stewart-Jones GBE, et al. Among authors: carfi a. Sci Transl Med. 2023 Sep 13;15(713):eadf4100. doi: 10.1126/scitranslmed.adf4100. Epub 2023 Sep 13. Sci Transl Med. 2023. PMID: 37703353
An mRNA-based platform for the delivery of pathogen-specific IgA into mucosal secretions.
Deal CE, Richards AF, Yeung T, Maron MJ, Wang Z, Lai YT, Fritz BR, Himansu S, Narayanan E, Liu D, Koleva R, Licht S, Hsiao CJ, Rajlic IL, Koch H, Kleyman M, Pulse ME, Weiss WJ, Doering JE, Lindberg SK, Mantis NJ, Carfi A, Plante OJ. Deal CE, et al. Among authors: carfi a. Cell Rep Med. 2023 Nov 21;4(11):101253. doi: 10.1016/j.xcrm.2023.101253. Epub 2023 Nov 1. Cell Rep Med. 2023. PMID: 37918405 Free PMC article.
mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies.
Xie Z, Lin YC, Steichen JM, Ozorowski G, Kratochvil S, Ray R, Torres JL, Liguori A, Kalyuzhniy O, Wang X, Warner JE, Weldon SR, Dale GA, Kirsch KH, Nair U, Baboo S, Georgeson E, Adachi Y, Kubitz M, Jackson AM, Richey ST, Volk RM, Lee JH, Diedrich JK, Prum T, Falcone S, Himansu S, Carfi A, Yates JR 3rd, Paulson JC, Sok D, Ward AB, Schief WR, Batista FD. Xie Z, et al. Among authors: carfi a. Science. 2024 May 17;384(6697):eadk0582. doi: 10.1126/science.adk0582. Epub 2024 May 17. Science. 2024. PMID: 38753770
mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models.
Wang X, Cottrell CA, Hu X, Ray R, Bottermann M, Villavicencio PM, Yan Y, Xie Z, Warner JE, Ellis-Pugh JR, Kalyuzhniy O, Liguori A, Willis JR, Menis S, Rämisch S, Eskandarzadeh S, Kubitz M, Tingle R, Phelps N, Groschel B, Himansu S, Carfi A, Kirsch KH, Weldon SR, Nair U, Schief WR, Batista FD. Wang X, et al. Among authors: carfi a. Sci Immunol. 2024 May 10;9(95):eadn0622. doi: 10.1126/sciimmunol.adn0622. Epub 2024 May 16. Sci Immunol. 2024. PMID: 38753808
210 results