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Pharmacometabolomics in TB Meningitis - understanding the pharmacokinetic, metabolic, and immune factors associated with anti-TB drug concentrations in cerebrospinal fluid.
Collins JM, Kipiani M, Jin Y, Sharma AA, Tomalka JA, Avaliani T, Gujabidze M, Bakuradze T, Sabanadze S, Avaliani Z, Blumberg HM, Benkeser D, Jones DP, Peloquin C, Kempker RR. Collins JM, et al. Among authors: tomalka ja. medRxiv [Preprint]. 2023 Dec 15:2023.12.14.23299982. doi: 10.1101/2023.12.14.23299982. medRxiv. 2023. PMID: 38168338 Free PMC article. Preprint.
Enhanced production of eicosanoids in plasma and activation of DNA damage pathways in PBMCs are correlated with the severity of ancestral COVID-19 infection.
Tomalka JA, Owings A, Galeas-Pena M, Ziegler CGK, Robinson TO, Wichman TG, Laird H, Williams HB, Dhaliwal NS, Everman S, Zafar Y, Shalek AK, Horwitz BH, Ordovas-Montanes J, Glover SC, Gibert Y. Tomalka JA, et al. medRxiv [Preprint]. 2023 Sep 15:2023.09.14.23295549. doi: 10.1101/2023.09.14.23295549. medRxiv. 2023. PMID: 37745424 Free PMC article. Preprint.
HIV vaccine candidate efficacy in female macaques mediated by cAMP-dependent efferocytosis and V2-specific ADCC.
Bissa M, Kim S, Galli V, Fourati S, Sarkis S, Arakelyan A, de Castro IS, Rahman MA, Fujiwara S, Vaccari M, Tomalka JA, Stamos JD, Schifanella L, Gorini G, Moles R, Gutowska A, Ferrari G, Lobanov A, Montefiori DC, Nelson GW, Cam MC, Chakhtoura M, Haddad EK, Doster MN, McKinnon K, Brown S, Venzon DJ, Choo-Wosoba H, Breed MW, Killoran KE, Kramer J, Margolis L, Sekaly RP, Hager GL, Franchini G. Bissa M, et al. Among authors: tomalka ja. Nat Commun. 2023 Feb 2;14(1):575. doi: 10.1038/s41467-023-36109-8. Nat Commun. 2023. PMID: 36732510 Free PMC article.
The transcription factor CREB1 is a mechanistic driver of immunogenicity and reduced HIV-1 acquisition following ALVAC vaccination.
Tomalka JA, Pelletier AN, Fourati S, Latif MB, Sharma A, Furr K, Carlson K, Lifton M, Gonzalez A, Wilkinson P, Franchini G, Parks R, Letvin N, Yates N, Seaton K, Tomaras G, Tartaglia J, Robb ML, Michael NL, Koup R, Haynes B, Santra S, Sekaly RP. Tomalka JA, et al. Nat Immunol. 2021 Oct;22(10):1294-1305. doi: 10.1038/s41590-021-01026-9. Epub 2021 Sep 23. Nat Immunol. 2021. PMID: 34556879 Free PMC article.
Negative regulation of FOXP3 expression by c-Rel O-GlcNAcylation.
de Jesus TJ, Tomalka JA, Centore JT, Staback Rodriguez FD, Agarwal RA, Liu AR, Kern TS, Ramakrishnan P. de Jesus TJ, et al. Among authors: tomalka ja. Glycobiology. 2021 Aug 7;31(7):812-826. doi: 10.1093/glycob/cwab001. Glycobiology. 2021. PMID: 33442719 Free PMC article.
Sam68 is a regulator of Toll-like receptor signaling.
Tomalka JA, de Jesus TJ, Ramakrishnan P. Tomalka JA, et al. Cell Mol Immunol. 2017 Jan;14(1):107-117. doi: 10.1038/cmi.2016.32. Epub 2016 Jul 4. Cell Mol Immunol. 2017. PMID: 27374795 Free PMC article.