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A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation.
Garnish SE, Martin KR, Kauppi M, Jackson VE, Ambrose R, Eng VV, Chiou S, Meng Y, Frank D, Tovey Crutchfield EC, Patel KM, Jacobsen AV, Atkin-Smith GK, Di Rago L, Doerflinger M, Horne CR, Hall C, Young SN, Cook M, Athanasopoulos V, Vinuesa CG, Lawlor KE, Wicks IP, Ebert G, Ng AP, Slade CA, Pearson JS, Samson AL, Silke J, Murphy JM, Hildebrand JM. Garnish SE, et al. Among authors: wicks ip. Nat Commun. 2023 Sep 28;14(1):6046. doi: 10.1038/s41467-023-41724-6. Nat Commun. 2023. PMID: 37770424 Free PMC article.
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.
Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE. Lawlor KE, et al. Among authors: wicks ip. Nat Commun. 2015 Feb 18;6:6282. doi: 10.1038/ncomms7282. Nat Commun. 2015. PMID: 25693118 Free PMC article.
MLKL deficiency protects against low-grade, sterile inflammation in aged mice.
Tovey Crutchfield EC, Garnish SE, Day J, Anderton H, Chiou S, Hempel A, Hall C, Patel KM, Gangatirkar P, Martin KR, Li Wai Suen CSN, Garnham AL, Kueh AJ, Wicks IP, Silke J, Nachbur U, Samson AL, Murphy JM, Hildebrand JM. Tovey Crutchfield EC, et al. Among authors: wicks ip. Cell Death Differ. 2023 Apr;30(4):1059-1071. doi: 10.1038/s41418-023-01121-4. Epub 2023 Feb 8. Cell Death Differ. 2023. PMID: 36755069 Free PMC article.
TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells.
Balka KR, Louis C, Saunders TL, Smith AM, Calleja DJ, D'Silva DB, Moghaddas F, Tailler M, Lawlor KE, Zhan Y, Burns CJ, Wicks IP, Miner JJ, Kile BT, Masters SL, De Nardo D. Balka KR, et al. Among authors: wicks ip. Cell Rep. 2020 Apr 7;31(1):107492. doi: 10.1016/j.celrep.2020.03.056. Cell Rep. 2020. PMID: 32268090 Free article.
G-CSF - A double edge sword in neutrophil mediated immunity.
Martin KR, Wong HL, Witko-Sarsat V, Wicks IP. Martin KR, et al. Among authors: wicks ip. Semin Immunol. 2021 Apr;54:101516. doi: 10.1016/j.smim.2021.101516. Epub 2021 Oct 30. Semin Immunol. 2021. PMID: 34728120 Review.
161 results