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Induction of broad multifunctional CD8+ and CD4+ T cells by hepatitis B virus antigen-based synthetic long peptides ex vivo.
Jansen DTSL, de Beijer MTA, Luijten RJ, Kwappenberg K, Wiekmeijer AS, Kessler AL, Pieterman RFA, Bouzid R, Krebber WJ, de Man RA, Melief CJM, Buschow SI. Jansen DTSL, et al. Among authors: melief cjm. Front Immunol. 2023 Sep 13;14:1163118. doi: 10.3389/fimmu.2023.1163118. eCollection 2023. Front Immunol. 2023. PMID: 37781393 Free PMC article.
Enhanced HPV16 E6/E7+ tumor eradication via induction of tumor-specific T cells by therapeutic vaccination with virosomes presenting synthetic long peptides.
Stegmann T, Wiekmeijer AS, Kwappenberg K, van Duikeren S, Bhoelan F, Bemelman D, Beenakker TJM, Krebber WJ, Arens R, Melief CJM. Stegmann T, et al. Among authors: melief cjm. Cancer Immunol Immunother. 2023 Aug;72(8):2851-2864. doi: 10.1007/s00262-023-03462-y. Epub 2023 May 24. Cancer Immunol Immunother. 2023. PMID: 37222770 Free PMC article.
Delayed vaccine-induced CD8+ T cell expansion by topoisomerase I inhibition mediates enhanced CD70-dependent tumor eradication.
van der Sluis TC, van Haften FJ, van Duikeren S, Pardieck IN, de Graaf JF, Vleeshouwers W, van der Maaden K, Melief CJM, van der Burg SH, Arens R. van der Sluis TC, et al. Among authors: melief cjm. J Immunother Cancer. 2023 Nov 29;11(11):e007158. doi: 10.1136/jitc-2023-007158. J Immunother Cancer. 2023. PMID: 38030302 Free PMC article.
Special Review: The future of Immunotherapy.
Melief CJM. Melief CJM. Immunother Adv. 2020 Nov 25;1(1):ltaa005. doi: 10.1093/immadv/ltaa005. eCollection 2021 Jan. Immunother Adv. 2020. PMID: 36756002 Free PMC article. Review.
Therapeutic Vaccination against Human Papillomavirus Type 16 for the Treatment of High-Grade Anal Intraepithelial Neoplasia in HIV+ Men.
Gosens KCM, van der Burg SH, Welters MJP, Boekestijn S, Loof NM, Quint WGV, van Noesel CJM, van der Wal AC, Richel O, Krebber WJTA, Melief CJM, de Vries HJC, Prins JM. Gosens KCM, et al. Among authors: melief cjm. Clin Cancer Res. 2023 Oct 13;29(20):4109-4117. doi: 10.1158/1078-0432.CCR-22-3361. Clin Cancer Res. 2023. PMID: 37540563
Intradermal vaccination of HPV-16 E6 synthetic peptides conjugated to an optimized Toll-like receptor 2 ligand shows safety and potent T cell immunogenicity in patients with HPV-16 positive (pre-)malignant lesions.
Speetjens FM, Welters MJP, Slingerland M, van Poelgeest MIE, de Vos van Steenwijk PJ, Roozen I, Boekestijn S, Loof NM, Zom GG, Valentijn ARPM, Krebber WJ, Meeuwenoord NJ, Janssen CAH, Melief CJM, van der Marel GA, Filippov DV, van der Burg SH, Gelderblom H, Ossendorp F. Speetjens FM, et al. Among authors: melief cjm. J Immunother Cancer. 2022 Oct;10(10):e005016. doi: 10.1136/jitc-2022-005016. J Immunother Cancer. 2022. PMID: 36261215 Free PMC article. Clinical Trial.
A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection.
Pardieck IN, van der Sluis TC, van der Gracht ETI, Veerkamp DMB, Behr FM, van Duikeren S, Beyrend G, Rip J, Nadafi R, Beyranvand Nejad E, Mülling N, Brasem DJ, Camps MGM, Myeni SK, Bredenbeek PJ, Kikkert M, Kim Y, Cicin-Sain L, Abdelaal T, van Gisbergen KPJM, Franken KLMC, Drijfhout JW, Melief CJM, Zondag GCM, Ossendorp F, Arens R. Pardieck IN, et al. Among authors: melief cjm. Nat Commun. 2022 Jul 8;13(1):3966. doi: 10.1038/s41467-022-31721-6. Nat Commun. 2022. PMID: 35803932 Free PMC article.
199 results