Kwong AD - Search Results

1

Evaluation of in vitro antiviral activity of SARS-CoV-2 M^pro inhibitor pomotrelvir and cross-resistance to nirmatrelvir resistance substitutions.

Tong X, Keung W, Arnold LD, Stevens LJ, Pruijssers AJ, Kook S, Lopatin U, Denison M, Kwong AD. Tong X, et al. Among authors: kwong ad. Antimicrob Agents Chemother. 2023 Nov 15;67(11):e0084023. doi: 10.1128/aac.00840-23. Epub 2023 Oct 6. Antimicrob Agents Chemother. 2023. PMID: 37800975 Free PMC article.

2

SARS-CoV-2 viral dynamics in a placebo-controlled phase 2 study of patients infected with the SARS-CoV-2 Omicron variant and treated with pomotrelvir.

Borroto-Esoda K, Wilfret D, Tong X, Plummer A, Kearney B, Kwong AD. Borroto-Esoda K, et al. Among authors: kwong ad. Microbiol Spectr. 2024 Feb 6;12(2):e0298023. doi: 10.1128/spectrum.02980-23. Epub 2024 Jan 10. Microbiol Spectr. 2024. PMID: 38197702 Free PMC article. Clinical Trial.

3

Accelerating antiviral drug discovery: lessons from COVID-19.

von Delft A, Hall MD, Kwong AD, Purcell LA, Saikatendu KS, Schmitz U, Tallarico JA, Lee AA. von Delft A, et al. Among authors: kwong ad. Nat Rev Drug Discov. 2023 Jul;22(7):585-603. doi: 10.1038/s41573-023-00692-8. Epub 2023 May 12. Nat Rev Drug Discov. 2023. PMID: 37173515 Free PMC article. Review.

4

Merimepodib, an IMPDH inhibitor, suppresses replication of Zika virus and other emerging viral pathogens.

Tong X, Smith J, Bukreyeva N, Koma T, Manning JT, Kalkeri R, Kwong AD, Paessler S. Tong X, et al. Among authors: kwong ad. Antiviral Res. 2018 Jan;149:34-40. doi: 10.1016/j.antiviral.2017.11.004. Epub 2017 Nov 8. Antiviral Res. 2018. PMID: 29126899

5

Preclinical activity of VX-787, a first-in-class, orally bioavailable inhibitor of the influenza virus polymerase PB2 subunit.

Byrn RA, Jones SM, Bennett HB, Bral C, Clark MP, Jacobs MD, Kwong AD, Ledeboer MW, Leeman JR, McNeil CF, Murcko MA, Nezami A, Perola E, Rijnbrand R, Saxena K, Tsai AW, Zhou Y, Charifson PS. Byrn RA, et al. Among authors: kwong ad. Antimicrob Agents Chemother. 2015 Mar;59(3):1569-82. doi: 10.1128/AAC.04623-14. Epub 2014 Dec 29. Antimicrob Agents Chemother. 2015. PMID: 25547360 Free PMC article.

6

Nonstructural protein 5A (NS5A) and human replication protein A increase the processivity of hepatitis C virus NS5B polymerase activity in vitro.

Mani N, Yuzhakov A, Yuzhakov O, Coll JT, Black J, Saxena K, Fulghum JR, Lippke JA, Rao BG, Rijnbrand R, Kwong AD. Mani N, et al. Among authors: kwong ad. J Virol. 2015 Jan;89(1):165-80. doi: 10.1128/JVI.01677-14. Epub 2014 Oct 15. J Virol. 2015. PMID: 25320291 Free PMC article.

7

Barrier to resistance: lessons from 2 direct-acting hepatitis C virus inhibitors, MK-5172 and Sofosbuvir.

Tong X, Kwong AD. Tong X, et al. Among authors: kwong ad. Clin Infect Dis. 2014 Dec 15;59(12):1675-7. doi: 10.1093/cid/ciu700. Epub 2014 Sep 28. Clin Infect Dis. 2014. PMID: 25266288 No abstract available.

8

Telaprevir-based treatment effects on hepatitis C virus in liver and blood.

Talal AH, Dimova RB, Zhang EZ, Jiang M, Penney MS, Sullivan JC, Botfield MC, Chakilam A, Sawant R, Cervini CM, Zeremski M, Jacobson IM, Kwong AD. Talal AH, et al. Among authors: kwong ad. Hepatology. 2014 Dec;60(6):1826-37. doi: 10.1002/hep.27202. Epub 2014 Jul 31. Hepatology. 2014. PMID: 24811404 Free PMC article.

9

The HCV Revolution Did Not Happen Overnight.

Kwong AD. Kwong AD. ACS Med Chem Lett. 2014 Mar 13;5(3):214-220. doi: 10.1021/ml500070q. ACS Med Chem Lett. 2014. PMID: 24672647 Free PMC article.

10

Restoration of the activated Rig-I pathway in hepatitis C virus (HCV) replicon cells by HCV protease, polymerase, and NS5A inhibitors in vitro at clinically relevant concentrations.

Kalkeri G, Lin C, Gopilan J, Sloan K, Rijnbrand R, Kwong AD. Kalkeri G, et al. Among authors: kwong ad. Antimicrob Agents Chemother. 2013 Sep;57(9):4417-26. doi: 10.1128/AAC.00399-13. Epub 2013 Jul 8. Antimicrob Agents Chemother. 2013. PMID: 23836176 Free PMC article.

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