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COX17 acetylation via MOF-KANSL complex promotes mitochondrial integrity and function.
Guhathakurta S, Erdogdu NU, Hoffmann JJ, Grzadzielewska I, Schendzielorz A, Seyfferth J, Mårtensson CU, Corrado M, Karoutas A, Warscheid B, Pfanner N, Becker T, Akhtar A. Guhathakurta S, et al. Among authors: akhtar a. Nat Metab. 2023 Nov;5(11):1931-1952. doi: 10.1038/s42255-023-00904-w. Epub 2023 Oct 9. Nat Metab. 2023. PMID: 37813994 Free PMC article.
MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria.
Chatterjee A, Seyfferth J, Lucci J, Gilsbach R, Preissl S, Böttinger L, Mårtensson CU, Panhale A, Stehle T, Kretz O, Sahyoun AH, Avilov S, Eimer S, Hein L, Pfanner N, Becker T, Akhtar A. Chatterjee A, et al. Among authors: akhtar a. Cell. 2016 Oct 20;167(3):722-738.e23. doi: 10.1016/j.cell.2016.09.052. Cell. 2016. PMID: 27768893 Free article.
The NSL complex maintains nuclear architecture stability via lamin A/C acetylation.
Karoutas A, Szymanski W, Rausch T, Guhathakurta S, Rog-Zielinska EA, Peyronnet R, Seyfferth J, Chen HR, de Leeuw R, Herquel B, Kimura H, Mittler G, Kohl P, Medalia O, Korbel JO, Akhtar A. Karoutas A, et al. Among authors: akhtar a. Nat Cell Biol. 2019 Oct;21(10):1248-1260. doi: 10.1038/s41556-019-0397-z. Epub 2019 Oct 1. Nat Cell Biol. 2019. PMID: 31576060
Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature.
Sheikh BN, Guhathakurta S, Tsang TH, Schwabenland M, Renschler G, Herquel B, Bhardwaj V, Holz H, Stehle T, Bondareva O, Aizarani N, Mossad O, Kretz O, Reichardt W, Chatterjee A, Braun LJ, Thevenon J, Sartelet H, Blank T, Grün D, von Elverfeldt D, Huber TB, Vestweber D, Avilov S, Prinz M, Buescher JM, Akhtar A. Sheikh BN, et al. Among authors: akhtar a. Nat Cell Biol. 2020 Jul;22(7):828-841. doi: 10.1038/s41556-020-0526-8. Epub 2020 Jun 15. Nat Cell Biol. 2020. PMID: 32541879
RNA nucleation by MSL2 induces selective X chromosome compartmentalization.
Valsecchi CIK, Basilicata MF, Georgiev P, Gaub A, Seyfferth J, Kulkarni T, Panhale A, Semplicio G, Manjunath V, Holz H, Dasmeh P, Akhtar A. Valsecchi CIK, et al. Among authors: akhtar a. Nature. 2021 Jan;589(7840):137-142. doi: 10.1038/s41586-020-2935-z. Epub 2020 Nov 18. Nature. 2021. PMID: 33208948
661 results