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The type-I interferon response potentiates seeded tau aggregation and exacerbates tau pathology.
Alzheimers Dement. 2024 Feb;20(2):1013-1025. doi: 10.1002/alz.13493. Epub 2023 Oct 17.
Alzheimers Dement. 2024.
PMID: 37849026
Free PMC article.
Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue.
Miller LVC, Mukadam AS, Durrant CS, Vaysburd MJ, Katsinelos T, Tuck BJ, Sanford S, Sheppard O, Knox C, Cheng S, James LC, Coleman MP, McEwan WA.
Miller LVC, et al.
Acta Neuropathol Commun. 2021 Mar 12;9(1):41. doi: 10.1186/s40478-021-01141-6.
Acta Neuropathol Commun. 2021.
PMID: 33712082
Free PMC article.
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Type-I Interferons in Alzheimer's Disease and Other Tauopathies.
Sanford SAI, McEwan WA.
Sanford SAI, et al.
Front Cell Neurosci. 2022 Jul 15;16:949340. doi: 10.3389/fncel.2022.949340. eCollection 2022.
Front Cell Neurosci. 2022.
PMID: 35910253
Free PMC article.
Review.
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Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.
Mukadam AS, Miller LVC, Smith AE, Vaysburd M, Sakya SA, Sanford S, Keeling S, Tuck BJ, Katsinelos T, Green C, Skov L, Kaalund SS, Foss S, Mayes K, O'Connell K, Wing M, Knox C, Banbury J, Avezov E, Rowe JB, Goedert M, Andersen JT, James LC, McEwan WA.
Mukadam AS, et al.
Science. 2023 Mar 31;379(6639):1336-1341. doi: 10.1126/science.abn1366. Epub 2023 Mar 30.
Science. 2023.
PMID: 36996217
Free PMC article.
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