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The type-I interferon response potentiates seeded tau aggregation and exacerbates tau pathology.
Alzheimers Dement. 2024 Feb;20(2):1013-1025. doi: 10.1002/alz.13493. Epub 2023 Oct 17.
Alzheimers Dement. 2024.
PMID: 37849026
Free PMC article.
Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue.
Miller LVC, Mukadam AS, Durrant CS, Vaysburd MJ, Katsinelos T, Tuck BJ, Sanford S, Sheppard O, Knox C, Cheng S, James LC, Coleman MP, McEwan WA.
Miller LVC, et al. Among authors: tuck bj.
Acta Neuropathol Commun. 2021 Mar 12;9(1):41. doi: 10.1186/s40478-021-01141-6.
Acta Neuropathol Commun. 2021.
PMID: 33712082
Free PMC article.
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Cholesterol determines the cytosolic entry and seeded aggregation of tau.
Tuck BJ, Miller LVC, Katsinelos T, Smith AE, Wilson EL, Keeling S, Cheng S, Vaysburd MJ, Knox C, Tredgett L, Metzakopian E, James LC, McEwan WA.
Tuck BJ, et al.
Cell Rep. 2022 May 3;39(5):110776. doi: 10.1016/j.celrep.2022.110776.
Cell Rep. 2022.
PMID: 35508140
Free PMC article.
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Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.
Mukadam AS, Miller LVC, Smith AE, Vaysburd M, Sakya SA, Sanford S, Keeling S, Tuck BJ, Katsinelos T, Green C, Skov L, Kaalund SS, Foss S, Mayes K, O'Connell K, Wing M, Knox C, Banbury J, Avezov E, Rowe JB, Goedert M, Andersen JT, James LC, McEwan WA.
Mukadam AS, et al. Among authors: tuck bj.
Science. 2023 Mar 31;379(6639):1336-1341. doi: 10.1126/science.abn1366. Epub 2023 Mar 30.
Science. 2023.
PMID: 36996217
Free PMC article.
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The Role of Antibodies and Their Receptors in Protection Against Ordered Protein Assembly in Neurodegeneration.
Katsinelos T, Tuck BJ, Mukadam AS, McEwan WA.
Katsinelos T, et al. Among authors: tuck bj.
Front Immunol. 2019 May 31;10:1139. doi: 10.3389/fimmu.2019.01139. eCollection 2019.
Front Immunol. 2019.
PMID: 31214163
Free PMC article.
Review.
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Super-resolution imaging unveils the self-replication of tau aggregates upon seeding.
Dimou E, Katsinelos T, Meisl G, Tuck BJ, Keeling S, Smith AE, Hidari E, Lam JYL, Burke M, Lövestam S, Ranasinghe RT, McEwan WA, Klenerman D.
Dimou E, et al. Among authors: tuck bj.
Cell Rep. 2023 Jul 25;42(7):112725. doi: 10.1016/j.celrep.2023.112725. Epub 2023 Jul 1.
Cell Rep. 2023.
PMID: 37393617
Free PMC article.
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Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells.
Rodríguez-Silvestre P, Laub M, Krawczyk PA, Davies AK, Schessner JP, Parveen R, Tuck BJ, McEwan WA, Borner GHH, Kozik P.
Rodríguez-Silvestre P, et al. Among authors: tuck bj.
Science. 2023 Jun 23;380(6651):1258-1265. doi: 10.1126/science.adg8802. Epub 2023 Jun 22.
Science. 2023.
PMID: 37347855
Free PMC article.
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