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Page 1
Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets.
Ohta A, Tanada M, Shinohara S, Morita Y, Nakano K, Yamagishi Y, Takano R, Kariyuki S, Iida T, Matsuo A, Ozeki K, Emura T, Sakurai Y, Takano K, Higashida A, Kojima M, Muraoka T, Takeyama R, Kato T, Kimura K, Ogawa K, Ohara K, Tanaka S, Kikuchi Y, Hisada N, Hayashi R, Nishimura Y, Nomura K, Tachibana T, Irie M, Kawada H, Torizawa T, Murao N, Kotake T, Tanaka M, Ishikawa S, Miyake T, Tamiya M, Arai M, Chiyoda A, Akai S, Sase H, Kuramoto S, Ito T, Shiraishi T, Kojima T, Iikura H. Ohta A, et al. Among authors: murao n. J Am Chem Soc. 2023 Nov 8;145(44):24035-24051. doi: 10.1021/jacs.3c07145. Epub 2023 Oct 24. J Am Chem Soc. 2023. PMID: 37874670
Exploitation of Elevated Extracellular ATP to Specifically Direct Antibody to Tumor Microenvironment.
Mimoto F, Tatsumi K, Shimizu S, Kadono S, Haraya K, Nagayasu M, Suzuki Y, Fujii E, Kamimura M, Hayasaka A, Kawauchi H, Ohara K, Matsushita M, Baba T, Susumu H, Sakashita T, Muraoka T, Aso K, Katada H, Tanaka E, Nakagawa K, Hasegawa M, Ayabe M, Yamamoto T, Tanba S, Ishiguro T, Kamikawa T, Nambu T, Kibayashi T, Azuma Y, Tomii Y, Kato A, Ozeki K, Murao N, Endo M, Kikuta J, Kamata-Sakurai M, Ishii M, Hattori K, Igawa T. Mimoto F, et al. Among authors: murao n. Cell Rep. 2020 Dec 22;33(12):108542. doi: 10.1016/j.celrep.2020.108542. Cell Rep. 2020. PMID: 33357423 Free article.
Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent.
Isshiki Y, Kohchi Y, Iikura H, Matsubara Y, Asoh K, Murata T, Kohchi M, Mizuguchi E, Tsujii S, Hattori K, Miura T, Yoshimura Y, Aida S, Miwa M, Saitoh R, Murao N, Okabe H, Belunis C, Janson C, Lukacs C, Schück V, Shimma N. Isshiki Y, et al. Among authors: murao n. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1795-801. doi: 10.1016/j.bmcl.2011.01.062. Epub 2011 Jan 21. Bioorg Med Chem Lett. 2011. PMID: 21316218
Highlights of the 13th Japan Bioanalysis Forum Symposium.
Yamaguchi T, Nishiguchi Y, Yamada N, Takahashi M, Uchiyama H, Niwa M, Koseki N, Nakamura T, Shimizu H, Komaba J, Arakawa T, Murao N. Yamaguchi T, et al. Among authors: murao n. Bioanalysis. 2022 Oct;14(19):1251-1255. doi: 10.4155/bio-2022-0191. Epub 2022 Dec 20. Bioanalysis. 2022. PMID: 36537280 Free article.
MHC-associated peptide proteomics enabling highly sensitive detection of immunogenic sequences for the development of therapeutic antibodies with low immunogenicity.
Sekiguchi N, Kubo C, Takahashi A, Muraoka K, Takeiri A, Ito S, Yano M, Mimoto F, Maeda A, Iwayanagi Y, Wakabayashi T, Takata S, Murao N, Chiba S, Ishigai M. Sekiguchi N, et al. Among authors: murao n. MAbs. 2018 Nov-Dec;10(8):1168-1181. doi: 10.1080/19420862.2018.1518888. Epub 2018 Oct 1. MAbs. 2018. PMID: 30199322 Free PMC article.
Highlights of the 12th Japan Bioanalysis Forum Symposium.
Uchiyama H, Yamaguchi T, Arai K, Arakawa T, Igarashi H, Ohtsu Y, Ochiai R, Kawai Y, Koseki N, Komaba J, Sano Y, Shimizu H, Takahashi M, Nagao A, Nakamura T, Nishiguchi Y, Hata K, Nakai K, Hara H, Mabuchi M, Murao N, Yoshinaga R. Uchiyama H, et al. Among authors: murao n. Bioanalysis. 2021 Nov;13(22):1653-1657. doi: 10.4155/bio-2021-0204. Epub 2021 Oct 18. Bioanalysis. 2021. PMID: 34657482 Free article.
Selective SGLT2 inhibition by tofogliflozin reduces renal glucose reabsorption under hyperglycemic but not under hypo- or euglycemic conditions in rats.
Nagata T, Fukazawa M, Honda K, Yata T, Kawai M, Yamane M, Murao N, Yamaguchi K, Kato M, Mitsui T, Suzuki Y, Ikeda S, Kawabe Y. Nagata T, et al. Among authors: murao n. Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E414-23. doi: 10.1152/ajpendo.00545.2012. Epub 2012 Dec 18. Am J Physiol Endocrinol Metab. 2013. PMID: 23249697 Free article.
108 results