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Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets.
Ohta A, Tanada M, Shinohara S, Morita Y, Nakano K, Yamagishi Y, Takano R, Kariyuki S, Iida T, Matsuo A, Ozeki K, Emura T, Sakurai Y, Takano K, Higashida A, Kojima M, Muraoka T, Takeyama R, Kato T, Kimura K, Ogawa K, Ohara K, Tanaka S, Kikuchi Y, Hisada N, Hayashi R, Nishimura Y, Nomura K, Tachibana T, Irie M, Kawada H, Torizawa T, Murao N, Kotake T, Tanaka M, Ishikawa S, Miyake T, Tamiya M, Arai M, Chiyoda A, Akai S, Sase H, Kuramoto S, Ito T, Shiraishi T, Kojima T, Iikura H. Ohta A, et al. J Am Chem Soc. 2023 Nov 8;145(44):24035-24051. doi: 10.1021/jacs.3c07145. Epub 2023 Oct 24. J Am Chem Soc. 2023. PMID: 37874670
Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor.
Tanada M, Tamiya M, Matsuo A, Chiyoda A, Takano K, Ito T, Irie M, Kotake T, Takeyama R, Kawada H, Hayashi R, Ishikawa S, Nomura K, Furuichi N, Morita Y, Kage M, Hashimoto S, Nii K, Sase H, Ohara K, Ohta A, Kuramoto S, Nishimura Y, Iikura H, Shiraishi T. Tanada M, et al. Among authors: ohta a. J Am Chem Soc. 2023 Aug 2;145(30):16610-16620. doi: 10.1021/jacs.3c03886. Epub 2023 Jul 18. J Am Chem Soc. 2023. PMID: 37463267
Associations between dietary potassium intake from different food sources and hyperkalemia in patients with chronic kidney disease.
Morimoto N, Shioji S, Akagi Y, Fujiki T, Mandai S, Ando F, Mori T, Susa K, Naito S, Sohara E, Anzai T, Takahashi K, Akita W, Ohta A, Uchida S, Iimori S. Morimoto N, et al. Among authors: ohta a. J Ren Nutr. 2024 Apr 13:S1051-2276(24)00058-X. doi: 10.1053/j.jrn.2024.03.008. Online ahead of print. J Ren Nutr. 2024. PMID: 38621432
[Kidney transplantation for end-stage renal disease after third allogeneic hematopoietic stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia].
Nishijima A, Shingai N, Ohta A, Suda K, Omoto K, Ishida S, Yoshioka K, Kurosawa S, Hino Y, Senoo Y, Igarashi A, Oshikawa G, Hamamura A, Toya T, Shimizu H, Najima Y, Kobayashi T, Haraguchi K, Okuyama Y, Ohashi K, Doki N. Nishijima A, et al. Among authors: ohta a. Rinsho Ketsueki. 2024;65(1):7-12. doi: 10.11406/rinketsu.65.7. Rinsho Ketsueki. 2024. PMID: 38311391 Japanese.
901 results