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KEAP1 mutation in lung adenocarcinoma promotes immune evasion and immunotherapy resistance.
Zavitsanou AM, Pillai R, Hao Y, Wu WL, Bartnicki E, Karakousi T, Rajalingam S, Herrera A, Karatza A, Rashidfarrokhi A, Solis S, Ciampricotti M, Yeaton AH, Ivanova E, Wohlhieter CA, Buus TB, Hayashi M, Karadal-Ferrena B, Pass HI, Poirier JT, Rudin CM, Wong KK, Moreira AL, Khanna KM, Tsirigos A, Papagiannakopoulos T, Koralov SB. Zavitsanou AM, et al. Among authors: wong kk. Cell Rep. 2023 Nov 28;42(11):113295. doi: 10.1016/j.celrep.2023.113295. Epub 2023 Oct 26. Cell Rep. 2023. PMID: 37889752 Free PMC article.
Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer.
Pillai R, LeBoeuf SE, Hao Y, New C, Blum JLE, Rashidfarrokhi A, Huang SM, Bahamon C, Wu WL, Karadal-Ferrena B, Herrera A, Ivanova E, Cross M, Bossowski JP, Ding H, Hayashi M, Rajalingam S, Karakousi T, Sayin VI, Khanna KM, Wong KK, Wild R, Tsirigos A, Poirier JT, Rudin CM, Davidson SM, Koralov SB, Papagiannakopoulos T. Pillai R, et al. Among authors: wong kk. bioRxiv [Preprint]. 2023 Jun 28:2023.06.27.546750. doi: 10.1101/2023.06.27.546750. bioRxiv. 2023. PMID: 37425844 Free PMC article. Updated. Preprint.
Tumor-intrinsic LKB1-LIF signaling axis establishes a myeloid niche to promote immune evasion and tumor growth.
Rashidfarrokhi A, Pillai R, Hao Y, Wu WL, Karadal-Ferrena B, Dimitriadoy SG, Cross M, Yeaton AH, Huang SM, Bhutkar AJ, Herrera A, Rajalingam S, Hayashi M, Huang KL, Bartnicki E, Zavitsanou AM, Wohlhieter CA, Leboeuf SE, Chen T, Loomis C, Mezzano V, Kulicke R, Davis FP, Stransky N, Smolen GA, Rudin CM, Moreira AL, Khanna KM, Pass HI, Wong KK, Koide S, Tsirigos A, Koralov SB, Papagiannakopoulos T. Rashidfarrokhi A, et al. Among authors: wong kk. bioRxiv [Preprint]. 2023 Jul 17:2023.07.15.549147. doi: 10.1101/2023.07.15.549147. bioRxiv. 2023. PMID: 37502974 Free PMC article. Preprint.
Neuroendocrine lineage commitment of small cell lung cancers can be leveraged into p53-independent non-cytotoxic therapy.
Biswas S, Kang K, Ng KP, Radivoyevitch T, Schalper K, Zhang H, Lindner DJ, Thomas A, MacPherson D, Gastman B, Schrump DS, Wong KK, Velcheti V, Saunthararajah Y. Biswas S, et al. Among authors: wong kk. Cell Rep. 2023 Aug 29;42(8):113016. doi: 10.1016/j.celrep.2023.113016. Epub 2023 Aug 18. Cell Rep. 2023. PMID: 37597186 Free PMC article.
EZH2 inhibition promotes tumor immunogenicity in lung squamous cell carcinomas.
DuCote TJ, Song X, Naughton KJ, Chen F, Plaugher DR, Childress AR, Edgin AR, Qu X, Liu J, Liu J, Li F, Wong KK, Brainson CF. DuCote TJ, et al. Among authors: wong kk. bioRxiv [Preprint]. 2023 Jun 8:2023.06.06.543919. doi: 10.1101/2023.06.06.543919. bioRxiv. 2023. PMID: 37333199 Free PMC article. Updated. Preprint.
LKB1 controls inflammatory potential through CRTC2-dependent histone acetylation.
Compton SE, Kitchen-Goosen SM, DeCamp LM, Lau KH, Mabvakure B, Vos M, Williams KS, Wong KK, Shi X, Rothbart SB, Krawczyk CM, Jones RG. Compton SE, et al. Among authors: wong kk. Mol Cell. 2023 Jun 1;83(11):1872-1886.e5. doi: 10.1016/j.molcel.2023.04.017. Epub 2023 May 11. Mol Cell. 2023. PMID: 37172591 Free article.
FGFR inhibition augments anti-PD-1 efficacy in murine FGFR3-mutant bladder cancer by abrogating immunosuppression.
Okato A, Utsumi T, Ranieri M, Zheng X, Zhou M, Pereira LD, Chen T, Kita Y, Wu D, Hyun H, Lee H, Gdowski AS, Raupp JD, Clark-Garvey S, Manocha U, Chafitz A, Sherman F, Stephens J, Rose TL, Milowsky MI, Wobker SE, Serody JS, Damrauer JS, Wong KK, Kim WY. Okato A, et al. Among authors: wong kk. J Clin Invest. 2024 Jan 16;134(2):e169241. doi: 10.1172/JCI169241. J Clin Invest. 2024. PMID: 38226620 Free PMC article.
Clinical validation of a cell-free DNA fragmentome assay for augmentation of lung cancer early detection.
Mazzone PJ, Bach PB, Carey J, Schonewolf CA, Bognar K, Ahluwalia MS, Cruz-Correa M, Gierada D, Kotagiri S, Lloyd K, Maldonado F, Ortendahl JD, Sequist LV, Silvestri GA, Tanner N, Thompson JC, Vachani A, Wong KK, Zaidi AH, Catallini J, Gershman A, Lumbard K, Millberg LK, Nawrocki J, Portwood C, Rangnekar A, Sheridan CC, Trivedi N, Wu T, Zong Y, Cotton L, Ryan A, Cisar C, Leal A, Dracopoli NC, Scharpf RB, Velculescu VE, Pike LRG. Mazzone PJ, et al. Among authors: wong kk. Cancer Discov. 2024 Jun 3. doi: 10.1158/2159-8290.CD-24-0519. Online ahead of print. Cancer Discov. 2024. PMID: 38829053
Enhancing neonatal thoracoscopic surgical training with rabbit model.
Fung ACH, Chung PHY, Chan IHY, Lau ECT, Wo JYH, Wong KKY. Fung ACH, et al. Among authors: wong kky. Heliyon. 2024 May 18;10(10):e31498. doi: 10.1016/j.heliyon.2024.e31498. eCollection 2024 May 30. Heliyon. 2024. PMID: 38807895 Free PMC article.
1,760 results