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Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation.
Zhang AMY, Xia YH, Lin JSH, Chu KH, Wang WCK, Ruiter TJJ, Yang JCC, Chen N, Chhuor J, Patil S, Cen HH, Rideout EJ, Richard VR, Schaeffer DF, Zahedi RP, Borchers CH, Johnson JD, Kopp JL. Zhang AMY, et al. Among authors: kopp jl. Cell Metab. 2023 Dec 5;35(12):2119-2135.e5. doi: 10.1016/j.cmet.2023.10.003. Epub 2023 Oct 31. Cell Metab. 2023. PMID: 37913768
Islet amyloid polypeptide does not suppress pancreatic cancer.
Taylor AJ, Panzhinskiy E, Orban PC, Lynn FC, Schaeffer DF, Johnson JD, Kopp JL, Verchere CB. Taylor AJ, et al. Among authors: kopp jl. Mol Metab. 2023 Feb;68:101667. doi: 10.1016/j.molmet.2023.101667. Epub 2023 Jan 5. Mol Metab. 2023. PMID: 36621763 Free PMC article.
Erratum. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes 2023;72:433-448.
Mastracci TL, Apte M, Amundadottir LT, Alvarsson A, Artandi S, Bellin MD, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, Ouaamari AE, Gaulton KJ, Geisz A, Goodarzi MO, Hara M, Hull-Meichle RL, Kleger A, Klein AP, Kopp JL, Kulkarni RN, Muzumdar MD, Naren AP, Oakes SA, Olesen SS, Phelps EA, Powers AC, Stabler CL, Tirkes T, Whitcomb DC, Yadav D, Yong J, Zaghloul NA, Pandol SJ, Sander M. Mastracci TL, et al. Among authors: kopp jl. Diabetes. 2023 Aug 1;72(8):1173. doi: 10.2337/db23-er08. Diabetes. 2023. PMID: 37116182 Free PMC article. No abstract available.
Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings.
Mastracci TL, Apte M, Amundadottir LT, Alvarsson A, Artandi S, Bellin MD, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, El Ouaamari A, Gaulton KJ, Geisz A, Goodarzi MO, Hara M, Hull-Meichle RL, Kleger A, Klein AP, Kopp JL, Kulkarni RN, Muzumdar MD, Naren AP, Oakes SA, Olesen SS, Phelps EA, Powers AC, Stabler CL, Tirkes T, Whitcomb DC, Yadav D, Yong J, Zaghloul NA, Sander M, Pandol SJ. Mastracci TL, et al. Among authors: kopp jl. Pancreas. 2022 Oct 1;51(9):1061-1073. doi: 10.1097/MPA.0000000000002170. Pancreas. 2022. PMID: 37078927 Free PMC article.
Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings.
Mastracci TL, Apte M, Amundadottir LT, Alvarsson A, Artandi S, Bellin MD, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, El Ouaamari A, Gaulton KJ, Geisz A, Goodarzi MO, Hara M, Hull-Meichle RL, Kleger A, Klein AP, Kopp JL, Kulkarni RN, Muzumdar MD, Naren AP, Oakes SA, Olesen SS, Phelps EA, Powers AC, Stabler CL, Tirkes T, Whitcomb DC, Yadav D, Yong J, Zaghloul NA, Pandol SJ, Sander M. Mastracci TL, et al. Among authors: kopp jl. Diabetes. 2023 Apr 1;72(4):433-448. doi: 10.2337/db22-0942. Diabetes. 2023. PMID: 36940317 Free PMC article. Review.
Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics.
Zhang AMY, Chu KH, Daly BF, Ruiter T, Dou Y, Yang JCC, de Winter TJJ, Chhuor J, Wang S, Flibotte S, Zhao YB, Hu X, Li H, Rideout EJ, Schaeffer DF, Johnson JD, Kopp JL. Zhang AMY, et al. Among authors: kopp jl. Cancer Metab. 2022 Feb 21;10(1):5. doi: 10.1186/s40170-022-00282-z. Cancer Metab. 2022. PMID: 35189981 Free PMC article.
Deletion of pancreas-specific miR-216a reduces beta-cell mass and inhibits pancreatic cancer progression in mice.
Erener S, Ellis CE, Ramzy A, Glavas MM, O'Dwyer S, Pereira S, Wang T, Pang J, Bruin JE, Riedel MJ, Baker RK, Webber TD, Lesina M, Blüher M, Algül H, Kopp JL, Herzig S, Kieffer TJ. Erener S, et al. Among authors: kopp jl. Cell Rep Med. 2021 Nov 11;2(11):100434. doi: 10.1016/j.xcrm.2021.100434. eCollection 2021 Nov 16. Cell Rep Med. 2021. PMID: 34841287 Free PMC article.
38 results