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Antagonism of the brain P2X7 ion channel attenuates repeated social defeat induced microglia reactivity, monocyte recruitment and anxiety-like behavior in male mice.
Biltz RG, Swanson SP, Draime N, Davis AC, Yin W, Goodman EJ, Gallagher NR, Bhattacharya A, Sheridan JF, Godbout JP. Biltz RG, et al. Among authors: gallagher nr. Brain Behav Immun. 2024 Jan;115:356-373. doi: 10.1016/j.bbi.2023.10.011. Epub 2023 Oct 31. Brain Behav Immun. 2024. PMID: 37914101
IL-1 Receptor-1 on Vglut2 + neurons in the hippocampus is critical for neuronal and behavioral sensitization after repeated social stress.
DiSabato DJ, Yin W, Biltz RG, Gallagher NR, Oliver B, Nemeth DP, Liu X, Sheridan JF, Quan N, Godbout JP. DiSabato DJ, et al. Among authors: gallagher nr. Brain Behav Immun Health. 2022 Oct 29;26:100547. doi: 10.1016/j.bbih.2022.100547. eCollection 2022 Dec. Brain Behav Immun Health. 2022. PMID: 36388133 Free PMC article.
Unique brain endothelial profiles activated by social stress promote cell adhesion, prostaglandin E2 signaling, hypothalamic-pituitary-adrenal axis modulation, and anxiety.
Yin W, Swanson SP, Biltz RG, Goodman EJ, Gallagher NR, Sheridan JF, Godbout JP. Yin W, et al. Among authors: gallagher nr. Neuropsychopharmacology. 2022 Dec;47(13):2271-2282. doi: 10.1038/s41386-022-01434-x. Epub 2022 Sep 14. Neuropsychopharmacology. 2022. PMID: 36104533 Free PMC article.