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Formaldehyde regulates S-adenosylmethionine biosynthesis and one-carbon metabolism.
Science. 2023 Nov 3;382(6670):eabp9201. doi: 10.1126/science.abp9201. Epub 2023 Nov 3.
Science. 2023.
PMID: 37917677
Distinct RNA N-demethylation pathways catalyzed by nonheme iron ALKBH5 and FTO enzymes enable regulation of formaldehyde release rates.
Toh JDW, Crossley SWM, Bruemmer KJ, Ge EJ, He D, Iovan DA, Chang CJ.
Toh JDW, et al.
Proc Natl Acad Sci U S A. 2020 Oct 13;117(41):25284-25292. doi: 10.1073/pnas.2007349117. Epub 2020 Sep 28.
Proc Natl Acad Sci U S A. 2020.
PMID: 32989163
Free PMC article.
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Polarisome scaffolder Spa2-mediated macromolecular condensation of Aip5 for actin polymerization.
Xie Y, Sun J, Han X, Turšić-Wunder A, Toh JDW, Hong W, Gao YG, Miao Y.
Xie Y, et al. Among authors: toh jdw.
Nat Commun. 2019 Nov 7;10(1):5078. doi: 10.1038/s41467-019-13125-1.
Nat Commun. 2019.
PMID: 31699995
Free PMC article.
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Single-nucleotide-resolution sequencing of human N6-methyldeoxyadenosine reveals strand-asymmetric clusters associated with SSBP1 on the mitochondrial genome.
Koh CWQ, Goh YT, Toh JDW, Neo SP, Ng SB, Gunaratne J, Gao YG, Quake SR, Burkholder WF, Goh WSS.
Koh CWQ, et al. Among authors: toh jdw.
Nucleic Acids Res. 2018 Dec 14;46(22):11659-11670. doi: 10.1093/nar/gky1104.
Nucleic Acids Res. 2018.
PMID: 30412255
Free PMC article.
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N(6)-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5.
Zou S, Toh JD, Wong KH, Gao YG, Hong W, Woon EC.
Zou S, et al.
Sci Rep. 2016 May 9;6:25677. doi: 10.1038/srep25677.
Sci Rep. 2016.
PMID: 27156733
Free PMC article.
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A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N6-methyladenosine demethylase FTO.
Toh JDW, Sun L, Lau LZM, Tan J, Low JJA, Tang CWQ, Cheong EJY, Tan MJH, Chen Y, Hong W, Gao YG, Woon ECY.
Toh JDW, et al.
Chem Sci. 2015 Jan 1;6(1):112-122. doi: 10.1039/c4sc02554g. Epub 2014 Sep 22.
Chem Sci. 2015.
PMID: 28553460
Free PMC article.
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