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Unique single molecule binding of cardiac myosin binding protein-C to actin and phosphorylation-dependent inhibition of actomyosin motility requires 17 amino acids of the motif domain.
Weith A, Sadayappan S, Gulick J, Previs MJ, Vanburen P, Robbins J, Warshaw DM. Weith A, et al. Among authors: previs mj. J Mol Cell Cardiol. 2012 Jan;52(1):219-27. doi: 10.1016/j.yjmcc.2011.09.019. Epub 2011 Sep 25. J Mol Cell Cardiol. 2012. PMID: 21978630 Free PMC article.
Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility.
Lynch TL 4th, Kumar M, McNamara JW, Kuster DWD, Sivaguru M, Singh RR, Previs MJ, Lee KH, Kuffel G, Zilliox MJ, Lin BL, Ma W, Gibson AM, Blaxall BC, Nieman ML, Lorenz JN, Leichter DM, Leary OP, Janssen PML, de Tombe PP, Gilbert RJ, Craig R, Irving T, Warshaw DM, Sadayappan S. Lynch TL 4th, et al. Among authors: previs mj. J Mol Cell Cardiol. 2021 Jul;156:33-44. doi: 10.1016/j.yjmcc.2021.03.009. Epub 2021 Mar 26. J Mol Cell Cardiol. 2021. PMID: 33781820 Free PMC article.
MYBPC3-c.772G>A mutation results in haploinsufficiency and altered myosin cycling kinetics in a patient induced stem cell derived cardiomyocyte model of hypertrophic cardiomyopathy.
Steczina S, Mohran S, Bailey LRJ, McMillen TS, Kooiker KB, Wood NB, Davis J, Previs MJ, Olivotto I, Pioner JM, Geeves MA, Poggesi C, Regnier M. Steczina S, et al. Among authors: previs mj. J Mol Cell Cardiol. 2024 Jun;191:27-39. doi: 10.1016/j.yjmcc.2024.04.010. Epub 2024 Apr 20. J Mol Cell Cardiol. 2024. PMID: 38648963
49 results