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A TRIM21-based bioPROTAC highlights the therapeutic benefit of HuR degradation.
Fletcher A, Clift D, de Vries E, Martinez Cuesta S, Malcolm T, Meghini F, Chaerkady R, Wang J, Chiang A, Weng SHS, Tart J, Wong E, Donohoe G, Rawlins P, Gordon E, Taylor JD, James L, Hunt J. Fletcher A, et al. Among authors: malcolm t. Nat Commun. 2023 Nov 4;14(1):7093. doi: 10.1038/s41467-023-42546-2. Nat Commun. 2023. PMID: 37925433 Free PMC article.
A simeprevir-inducible molecular switch for the control of cell and gene therapies.
Chin SE, Schindler C, Vinall L, Dodd RB, Bamber L, Legg S, Sigurdardottir A, Rees DG, Malcolm TIM, Spratley SJ, Granéli C, Sumner J, Tigue NJ. Chin SE, et al. Among authors: malcolm tim. Nat Commun. 2023 Nov 27;14(1):7753. doi: 10.1038/s41467-023-43484-9. Nat Commun. 2023. PMID: 38012128 Free PMC article.
STAT3 regulated ARF expression suppresses prostate cancer metastasis.
Pencik J, Schlederer M, Gruber W, Unger C, Walker SM, Chalaris A, Marié IJ, Hassler MR, Javaheri T, Aksoy O, Blayney JK, Prutsch N, Skucha A, Herac M, Krämer OH, Mazal P, Grebien F, Egger G, Poli V, Mikulits W, Eferl R, Esterbauer H, Kennedy R, Fend F, Scharpf M, Braun M, Perner S, Levy DE, Malcolm T, Turner SD, Haitel A, Susani M, Moazzami A, Rose-John S, Aberger F, Merkel O, Moriggl R, Culig Z, Dolznig H, Kenner L. Pencik J, et al. Among authors: malcolm t. Nat Commun. 2015 Jul 22;6:7736. doi: 10.1038/ncomms8736. Nat Commun. 2015. PMID: 26198641 Free PMC article.
Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress.
Malcolm TI, Villarese P, Fairbairn CJ, Lamant L, Trinquand A, Hook CE, Burke GA, Brugières L, Hughes K, Payet D, Merkel O, Schiefer AI, Ashankyty I, Mian S, Wasik M, Turner M, Kenner L, Asnafi V, Macintyre E, Turner SD. Malcolm TI, et al. Nat Commun. 2016 Jan 12;7:10087. doi: 10.1038/ncomms10087. Nat Commun. 2016. PMID: 26753883 Free PMC article.
Erratum: STAT3 regulated ARF expression suppresses prostate cancer metastasis.
Pencik J, Schlederer M, Gruber W, Unger C, Walker SM, Chalaris A, Marié IJ, Hassler MR, Javaheri T, Aksoy O, Blayney JK, Prutsch N, Skucha A, Herac M, Krämer OH, Mazal P, Grebien F, Egger G, Poli V, Mikulits W, Eferl R, Esterbauer H, Kennedy R, Fend F, Scharpf M, Braun M, Perner S, Levy DE, Malcolm T, Turner SD, Haitel A, Susani M, Moazzami A, Rose-John S, Aberger F, Merkel O, Moriggl R, Culig Z, Dolznig H, Kenner L. Pencik J, et al. Among authors: malcolm t. Nat Commun. 2015 Oct 26;6:8802. doi: 10.1038/ncomms9802. Nat Commun. 2015. PMID: 26499136 Free PMC article. No abstract available.
Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy.
Creek D, Giannangelo C, Challis M, Siddiqui G, Edgar R, Malcolm T, Webb C, Drinkwater N, Vinh N, MacRaild C, Counihan N, Duffy S, Wittlin S, Devine S, Avery V, de Koning-Ward T, Scammells P, McGowan S. Creek D, et al. Among authors: malcolm t. Res Sq [Preprint]. 2024 Apr 26:rs.3.rs-3251230. doi: 10.21203/rs.3.rs-3251230/v3. Res Sq. 2024. PMID: 38746424 Free PMC article. Preprint.
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity.
Edgar RCS, Malcolm TR, Siddiqui G, Giannangelo C, Counihan NA, Challis M, Duffy S, Chowdhury M, Marfurt J, Dans M, Wirjanata G, Noviyanti R, Daware K, Suraweera CD, Price RN, Wittlin S, Avery VM, Drinkwater N, Charman SA, Creek DJ, de Koning-Ward TF, Scammells PJ, McGowan S. Edgar RCS, et al. Among authors: malcolm tr. mBio. 2024 May 8:e0096624. doi: 10.1128/mbio.00966-24. Online ahead of print. mBio. 2024. PMID: 38717141 Free article.
The reported impact of non-communicable disease investment cases in 13 countries.
Troisi G, Small R, Chestnov R, Andreasyan D, Khachatryan H, Phillips EA, Malcolm T, Kol H, Khodjaeva N, Gebremichael M, Worku Tessema A, Workneh AB, Davidson T, Harris M, Ibraeva N, Nurmatova A, Altymysheva A, Go JJ, Kontsevaya A, Hanbunjerd K, Bunluesin S, Nieveras O, Ekinci B, Keskinkiliç B, Erguder T, Akiya OC, Kasule H, Nakanjako A, Shukurov S, Kasymova N, Banda P, Kakoma E, Bakyaita NN, Kulikov A, Tarlton D, Putoud N, Chiossi S, Webb D, Banatvala N. Troisi G, et al. Among authors: malcolm t. BMJ Glob Health. 2024 Apr 10;9(4):e014784. doi: 10.1136/bmjgh-2023-014784. BMJ Glob Health. 2024. PMID: 38599663 Free PMC article.
76 results