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Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.
Boby ML, Fearon D, Ferla M, Filep M, Koekemoer L, Robinson MC; COVID Moonshot Consortium‡; Chodera JD, Lee AA, London N, von Delft A, von Delft F, Achdout H, Aimon A, Alonzi DS, Arbon R, Aschenbrenner JC, Balcomb BH, Bar-David E, Barr H, Ben-Shmuel A, Bennett J, Bilenko VA, Borden B, Boulet P, Bowman GR, Brewitz L, Brun J, Bvnbs S, Calmiano M, Carbery A, Carney DW, Cattermole E, Chang E, Chernyshenko E, Clyde A, Coffland JE, Cohen G, Cole JC, Contini A, Cox L, Croll TI, Cvitkovic M, De Jonghe S, Dias A, Donckers K, Dotson DL, Douangamath A, Duberstein S, Dudgeon T, Dunnett LE, Eastman P, Erez N, Eyermann CJ, Fairhead M, Fate G, Fedorov O, Fernandes RS, Ferrins L, Foster R, Foster H, Fraisse L, Gabizon R, García-Sastre A, Gawriljuk VO, Gehrtz P, Gileadi C, Giroud C, Glass WG, Glen RC, Glinert I, Godoy AS, Gorichko M, Gorrie-Stone T, Griffen EJ, Haneef A, Hassell Hart S, Heer J, Henry M, Hill M, Horrell S, Huang QYJ, Huliak VD, Hurley MFD, Israely T, Jajack A, Jansen J, Jnoff E, Jochmans D, John T, Kaminow B, Kang L, Kantsadi AL, Kenny PW, Kiappes JL, Kinakh SO, Kovar B, Krojer T, La VNT, Laghnimi-Hahn S, Lefker BA, Levy H, Lithgo RM, Logvinenko IG, Lukacik P, Macdonald HB, MacLean … See abstract for full author list ➔ Boby ML, et al. Among authors: spencer j. Science. 2023 Nov 10;382(6671):eabo7201. doi: 10.1126/science.abo7201. Epub 2023 Nov 10. Science. 2023. PMID: 37943932 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 35511995
[No title available]
[No authors listed] [No authors listed] PMID: 35536905
Harvesting and amplifying gene cassettes confers cross-resistance to critically important antibiotics.
Dulyayangkul P, Beavis T, Lee WWY, Ardagh R, Edwards F, Hamilton F, Head I, Heesom KJ, Mounsey O, Murarik M, Pinweha P, Reding C, Satapoomin N, Shaw JM, Takebayashi Y, Tooke CL, Spencer J, Williams PB, Avison MB. Dulyayangkul P, et al. Among authors: spencer j. PLoS Pathog. 2024 Jun 6;20(6):e1012235. doi: 10.1371/journal.ppat.1012235. eCollection 2024 Jun. PLoS Pathog. 2024. PMID: 38843111 Free PMC article.
The cost-effectiveness of procalcitonin for guiding antibiotic prescribing in individuals hospitalized with COVID-19: part of the PEACH study.
Webb EJD, Howdon D, Bestwick R, King N, Sandoe JAT, Euden J, Grozeva D, West R, Howard P, Powell N, Albur M, Bond S, Brookes-Howell L, Dark P, Hellyer T, Llewelyn M, McCullagh IJ, Ogden M, Pallmann P, Parsons H, Partridge D, Shaw D, Szakmany T, Todd S, Thomas-Jones E, Carrol ED, Shinkins B; PEACH Study Group. Webb EJD, et al. J Antimicrob Chemother. 2024 Jun 6:dkae167. doi: 10.1093/jac/dkae167. Online ahead of print. J Antimicrob Chemother. 2024. PMID: 38842487
A contact binary satellite of the asteroid (152830) Dinkinesh.
Levison HF, Marchi S, Noll KS, Spencer JR, Statler TS, Bell JF 3rd, Bierhaus EB, Binzel R, Bottke WF, Britt D, Brown ME, Buie MW, Christensen PR, Dello Russo N, Emery JP, Grundy WM, Hahn M, Hamilton VE, Howett C, Kaplan H, Kretke K, Lauer TR, Manzoni C, Marschall R, Martin AC, May BH, Mottola S, Olkin CB, Pätzold M, Parker JW, Porter S, Preusker F, Protopapa S, Reuter DC, Robbins SJ, Salmon J, Simon AA, Stern SA, Sunshine JM, Wong I, Weaver HA, Adam C, Ancheta S, Andrews J, Anwar S, Barnouin OS, Beasley M, Berry KE, Birath E, Bolin B, Booco M, Burns R, Campbell P, Carpenter R, Crombie K, Effertz M, Eifert E, Ellis C, Faiks P, Fischetti J, Fleming P, Francis K, Franco R, Freund S, Gallagher C, Geeraert J, Gobat C, Gorgas D, Granat C, Gray S, Haas P, Harch A, Hegedus K, Isabelle C, Jackson B, Jacob T, Jennings S, Kaufmann D, Keeney BA, Kennedy T, Lauffer K, Lessac-Chenen E, Leonard R, Levine A, Lunsford A, Martin T, McAdams J, Mehall G, Merkley T, Miller G, Montanaro M, Montgomery A, Murphy G, Myers M, Nelson DS, Ocampo A, Olds R, Pelgrift JY, Perkins T, Pineau J, Poland D, Ramanan V, Rose D, Sahr E, Short O, Solanki I, Stanbridge D, Sutter B, Talpas Z, Taylor H, Treiu B, Ver… See abstract for full author list ➔ Levison HF, et al. Among authors: spencer jr. Nature. 2024 May;629(8014):1015-1020. doi: 10.1038/s41586-024-07378-0. Epub 2024 May 29. Nature. 2024. PMID: 38811709 Free PMC article.
3,059 results