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Dual intron-targeted CRISPR-Cas9-mediated disruption of the AML RUNX1-RUNX1T1 fusion gene effectively inhibits proliferation and decreases tumor volume in vitro and in vivo.
Neldeborg S, Soerensen JF, Møller CT, Bill M, Gao Z, Bak RO, Holm K, Sorensen B, Nyegaard M, Luo Y, Hokland P, Stougaard M, Ludvigsen M, Holm CK. Neldeborg S, et al. Among authors: moller ct. Leukemia. 2023 Sep;37(9):1792-1801. doi: 10.1038/s41375-023-01950-9. Epub 2023 Jul 18. Leukemia. 2023. PMID: 37464068 Free PMC article.
Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling.
Hansen AL, Buchan GJ, Rühl M, Mukai K, Salvatore SR, Ogawa E, Andersen SD, Iversen MB, Thielke AL, Gunderstofte C, Motwani M, Møller CT, Jakobsen AS, Fitzgerald KA, Roos J, Lin R, Maier TJ, Goldbach-Mansky R, Miner CA, Qian W, Miner JJ, Rigby RE, Rehwinkel J, Jakobsen MR, Arai H, Taguchi T, Schopfer FJ, Olagnier D, Holm CK. Hansen AL, et al. Among authors: moller ct. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7768-E7775. doi: 10.1073/pnas.1806239115. Epub 2018 Jul 30. Proc Natl Acad Sci U S A. 2018. PMID: 30061387 Free PMC article.
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Möller CT. Möller CT. S Afr Med J. 1980 Aug 30;58(9):349. S Afr Med J. 1980. PMID: 7404251 No abstract available.