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Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity.
Fan H, Xia S, Xiang J, Li Y, Ross MO, Lim SA, Yang F, Tu J, Xie L, Dougherty U, Zhang FQ, Zheng Z, Zhang R, Wu R, Dong L, Su R, Chen X, Althaus T, Riedell PA, Jonker PB, Muir A, Lesinski GB, Rafiq S, Dhodapkar MV, Stock W, Odenike O, Patel AA, Opferman J, Tsuji T, Matsuzaki J, Shah H, Faubert B, Elf SE, Layden B, Bissonnette BM, He YY, Kline J, Mao H, Odunsi K, Gao X, Chi H, He C, Chen J. Fan H, et al. Among authors: chi h. Nature. 2023 Nov;623(7989):1034-1043. doi: 10.1038/s41586-023-06749-3. Epub 2023 Nov 22. Nature. 2023. PMID: 37993715 Free PMC article.
Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity.
Karmaus PWF, Chen X, Lim SA, Herrada AA, Nguyen TM, Xu B, Dhungana Y, Rankin S, Chen W, Rosencrance C, Yang K, Fan Y, Cheng Y, Easton J, Neale G, Vogel P, Chi H. Karmaus PWF, et al. Among authors: chi h. Nature. 2019 Jan;565(7737):101-105. doi: 10.1038/s41586-018-0806-7. Epub 2018 Dec 19. Nature. 2019. PMID: 30568299 Free PMC article.
Metabolic coordination of T cell quiescence and activation.
Chapman NM, Boothby MR, Chi H. Chapman NM, et al. Among authors: chi h. Nat Rev Immunol. 2020 Jan;20(1):55-70. doi: 10.1038/s41577-019-0203-y. Epub 2019 Aug 12. Nat Rev Immunol. 2020. PMID: 31406325 Review.
Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy.
Wei J, Long L, Zheng W, Dhungana Y, Lim SA, Guy C, Wang Y, Wang YD, Qian C, Xu B, Kc A, Saravia J, Huang H, Yu J, Doench JG, Geiger TL, Chi H. Wei J, et al. Among authors: chi h. Nature. 2019 Dec;576(7787):471-476. doi: 10.1038/s41586-019-1821-z. Epub 2019 Dec 11. Nature. 2019. PMID: 31827283 Free PMC article.
Signaling networks in immunometabolism.
Saravia J, Raynor JL, Chapman NM, Lim SA, Chi H. Saravia J, et al. Among authors: chi h. Cell Res. 2020 Apr;30(4):328-342. doi: 10.1038/s41422-020-0301-1. Epub 2020 Mar 20. Cell Res. 2020. PMID: 32203134 Free PMC article. Review.
Lipid signalling enforces functional specialization of Treg cells in tumours.
Lim SA, Wei J, Nguyen TM, Shi H, Su W, Palacios G, Dhungana Y, Chapman NM, Long L, Saravia J, Vogel P, Chi H. Lim SA, et al. Among authors: chi h. Nature. 2021 Mar;591(7849):306-311. doi: 10.1038/s41586-021-03235-6. Epub 2021 Feb 24. Nature. 2021. PMID: 33627871 Free PMC article.
Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia.
Gocho Y, Liu J, Hu J, Yang W, Dharia NV, Zhang J, Shi H, Du G, John A, Lin TN, Hunt J, Huang X, Ju B, Rowland L, Shi L, Maxwell D, Smart B, Crews KR, Yang W, Hagiwara K, Zhang Y, Roberts K, Wang H, Jabbour E, Stock W, Eisfelder B, Paietta E, Newman S, Roti G, Litzow M, Easton J, Zhang J, Peng J, Chi H, Pounds S, Relling MV, Inaba H, Zhu X, Kornblau S, Pui CH, Konopleva M, Teachey D, Mullighan CG, Stegmaier K, Evans WE, Yu J, Yang JJ. Gocho Y, et al. Among authors: chi h. Nat Cancer. 2021 Mar;2(3):284-299. doi: 10.1038/s43018-020-00167-4. Epub 2021 Jan 21. Nat Cancer. 2021. PMID: 34151288 Free PMC article.
2,291 results