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HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes.
Li W, Qin Z, Nand E, Grunst MW, Grover JR, Bess JW Jr, Lifson JD, Zwick MB, Tagare HD, Uchil PD, Mothes W. Li W, et al. Among authors: lifson jd. Nature. 2023 Nov;623(7989):1026-1033. doi: 10.1038/s41586-023-06762-6. Epub 2023 Nov 22. Nature. 2023. PMID: 37993716 Free PMC article.
Deep analysis of CD4 T cells in the rhesus CNS during SIV infection.
Elizaldi SR, Verma A, Ma ZM, Ott S, Rajasundaram D, Hawes CE, Lakshmanappa YS, Cottrell ML, Kashuba ADM, Ambrose Z, Lifson JD, Morrison JH, Iyer SS. Elizaldi SR, et al. Among authors: lifson jd. PLoS Pathog. 2023 Dec 7;19(12):e1011844. doi: 10.1371/journal.ppat.1011844. eCollection 2023 Dec. PLoS Pathog. 2023. PMID: 38060615 Free PMC article.
Early antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir.
Keele BF, Okoye AA, Fennessey CM, Varco-Merth B, Immonen TT, Kose E, Conchas A, Pinkevych M, Lipkey L, Newman L, Macairan A, Bosche M, Bosche WJ, Berkemeier B, Fast R, Hull M, Oswald K, Shoemaker R, Silipino L, Gorelick RJ, Duell D, Marenco A, Brantley W, Smedley J, Axthelm M, Davenport MP, Lifson JD, Picker LJ. Keele BF, et al. Among authors: lifson jd. PLoS Pathog. 2024 Apr 9;20(4):e1012135. doi: 10.1371/journal.ppat.1012135. eCollection 2024 Apr. PLoS Pathog. 2024. PMID: 38593120 Free PMC article.
Potent antibody-dependent cellular cytotoxicity of a V2-specific antibody is not sufficient for protection of macaques against SIV challenge.
Grunst MW, Gil HM, Grandea AG 3rd, Snow BJ, Andrabi R, Nedellec R, Burton I, Clark NM, Janaka SK, Keles NK, Moriarty RV, Weiler AM, Capuano S 3rd, Fennessey CM, Friedrich TC, O'Connor SL, O'Connor DH, Broman AT, Keele BF, Lifson JD, Hangartner L, Burton DR, Evans DT. Grunst MW, et al. Among authors: lifson jd. PLoS Pathog. 2024 Jan 22;20(1):e1011819. doi: 10.1371/journal.ppat.1011819. eCollection 2024 Jan. PLoS Pathog. 2024. PMID: 38252675 Free PMC article.
Lymphoid tissues contribute to plasma viral clonotypes early after antiretroviral therapy interruption in SIV-infected rhesus macaques.
Solis-Leal A, Boby N, Mallick S, Cheng Y, Wu F, De La Torre G, Dufour J, Alvarez X, Shivanna V, Liu Y, Fennessey CM, Lifson JD, Li Q, Keele BF, Ling B. Solis-Leal A, et al. Among authors: lifson jd. Sci Transl Med. 2023 Dec 13;15(726):eadi9867. doi: 10.1126/scitranslmed.adi9867. Epub 2023 Dec 13. Sci Transl Med. 2023. PMID: 38091409
The Impact of SIV-Induced Immunodeficiency on Clinical Manifestation, Immune Response, and Viral Dynamics in SARS-CoV-2 Coinfection.
Melton A, Rowe LA, Penney T, Krzykwa C, Goff K, Scheuermann S, Melton HJ, Williams K, Golden N, Green KM, Smith B, Russell-Lodrigue K, Dufour JP, Doyle-Meyers LA, Schiro F, Aye PP, Lifson JD, Beddingfield BJ, Blair RV, Bohm RP, Kolls JK, Rappaport J, Hoxie JA, Maness NJ. Melton A, et al. Among authors: lifson jd. bioRxiv [Preprint]. 2023 Nov 16:2023.11.15.567132. doi: 10.1101/2023.11.15.567132. bioRxiv. 2023. PMID: 38014096 Free PMC article. Preprint.
AZD5582 plus SIV-specific antibodies reduce lymph node viral reservoirs in antiretroviral therapy-suppressed macaques.
Dashti A, Sukkestad S, Horner AM, Neja M, Siddiqi Z, Waller C, Goldy J, Monroe D, Lin A, Schoof N, Singh V, Mavigner M, Lifson JD, Deleage C, Tuyishime M, Falcinelli SD, King HAD, Ke R, Mason RD, Archin NM, Dunham RM, Safrit JT, Jean S, Perelson AS, Margolis DM, Ferrari G, Roederer M, Silvestri G, Chahroudi A. Dashti A, et al. Among authors: lifson jd. Nat Med. 2023 Oct;29(10):2535-2546. doi: 10.1038/s41591-023-02570-7. Epub 2023 Oct 2. Nat Med. 2023. PMID: 37783968 Free PMC article.
CD4 T cell Responses in the CNS during SIV infection.
Elizaldi SR, Verma A, Ma ZM, Ott S, Rajasundaram D, Cottrell ML, Kashuba ADM, Ambrose Z, Lifson JD, Morrison JH, Iyer SS. Elizaldi SR, et al. Among authors: lifson jd. bioRxiv [Preprint]. 2023 Aug 25:2023.08.24.554055. doi: 10.1101/2023.08.24.554055. bioRxiv. 2023. PMID: 37662237 Free PMC article. Updated. Preprint.
Long-acting lenacapavir protects macaques against intravenous challenge with simian-tropic HIV.
Swanstrom AE, Gorelick RJ, Welker JL, Schmidt F, Lu B, Wang K, Rowe W, Breed MW, Killoran KE, Kramer JA, Donohue D, Roser JD, Bieniasz PD, Hatziioannou T, Pyle C, Thomas JA, Trubey CM, Zheng J, Blair W, Yant SR, Lifson JD, Del Prete GQ. Swanstrom AE, et al. Among authors: lifson jd. EBioMedicine. 2023 Sep;95:104764. doi: 10.1016/j.ebiom.2023.104764. Epub 2023 Aug 23. EBioMedicine. 2023. PMID: 37625266 Free PMC article.
424 results