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Page 1
Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies.
Nicosia L, Spencer GJ, Brooks N, Amaral FMR, Basma NJ, Chadwick JA, Revell B, Wingelhofer B, Maiques-Diaz A, Sinclair O, Camera F, Ciceri F, Wiseman DH, Pegg N, West W, Knurowski T, Frese K, Clegg K, Campbell VL, Cavet J, Copland M, Searle E, Somervaille TCP. Nicosia L, et al. Among authors: amaral fmr. Cancer Cell. 2023 Dec 11;41(12):2136-2153.e13. doi: 10.1016/j.ccell.2023.11.001. Epub 2023 Nov 22. Cancer Cell. 2023. PMID: 37995682 Free article.
Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia.
Maiques-Diaz A, Spencer GJ, Lynch JT, Ciceri F, Williams EL, Amaral FMR, Wiseman DH, Harris WJ, Li Y, Sahoo S, Hitchin JR, Mould DP, Fairweather EE, Waszkowycz B, Jordan AM, Smith DL, Somervaille TCP. Maiques-Diaz A, et al. Among authors: amaral fmr. Cell Rep. 2018 Mar 27;22(13):3641-3659. doi: 10.1016/j.celrep.2018.03.012. Cell Rep. 2018. PMID: 29590629 Free PMC article.
Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.
Simeoni F, Romero-Camarero I, Camera F, Amaral FMR, Sinclair OJ, Papachristou EK, Spencer GJ, Lie-A-Ling M, Lacaud G, Wiseman DH, Carroll JS, Somervaille TCP. Simeoni F, et al. Among authors: amaral fmr. Cell Rep. 2021 Sep 21;36(12):109725. doi: 10.1016/j.celrep.2021.109725. Cell Rep. 2021. PMID: 34551306 Free PMC article.
HMG20B stabilizes association of LSD1 with GFI1 on chromatin to confer transcription repression and leukemia cell differentiation block.
Maiques-Diaz A, Nicosia L, Basma NJ, Romero-Camarero I, Camera F, Spencer GJ, Amaral FMR, Simeoni F, Wingelhofer B, Williamson AJK, Pierce A, Whetton AD, Somervaille TCP. Maiques-Diaz A, et al. Among authors: amaral fmr. Oncogene. 2022 Oct;41(44):4841-4854. doi: 10.1038/s41388-022-02471-y. Epub 2022 Sep 28. Oncogene. 2022. PMID: 36171271 Free PMC article.
EVI1 phosphorylation at S436 regulates interactions with CtBP1 and DNMT3A and promotes self-renewal.
Paredes R, Kelly JR, Geary B, Almarzouq B, Schneider M, Pearson S, Narayanan P, Williamson A, Lovell SC, Wiseman DH, Chadwick JA, Jones NJ, Kustikova O, Schambach A, Garner T, Amaral FMR, Pierce A, Stevens A, Somervaille TCP, Whetton AD, Meyer S. Paredes R, et al. Among authors: amaral fmr. Cell Death Dis. 2020 Oct 20;11(10):878. doi: 10.1038/s41419-020-03099-0. Cell Death Dis. 2020. PMID: 33082307 Free PMC article.
Higher MDMX expression was associated with hypomethylating agent resistance and inferior survival in MDS patients, inferring it a potential therapeutic target.
Wang YH, Lin CC, Gurashi K, Wingelhofer B, Amaral FMR, Yao CY, Hsieh HT, Liu MC, Hou HA, Chou WC, Batta K, Wiseman DH, Tien HF. Wang YH, et al. Among authors: amaral fmr. Leukemia. 2023 Dec;37(12):2507-2511. doi: 10.1038/s41375-023-02044-2. Epub 2023 Nov 2. Leukemia. 2023. PMID: 37919605 No abstract available.
18 results