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Rational immunosilencing of a promiscuous T-cell epitope in the capsid of an adeno-associated virus.
Nat Biomed Eng. 2024 Feb;8(2):193-200. doi: 10.1038/s41551-023-01129-8. Epub 2023 Nov 23.
Nat Biomed Eng. 2024.
PMID: 37996615
Differential T cell immune responses to deamidated adeno-associated virus vector.
Bing SJ, Justesen S, Wu WW, Sajib AM, Warrington S, Baer A, Thorgrimsen S, Shen RF, Mazor R.
Bing SJ, et al.
Mol Ther Methods Clin Dev. 2022 Jan 18;24:255-267. doi: 10.1016/j.omtm.2022.01.005. eCollection 2022 Mar 10.
Mol Ther Methods Clin Dev. 2022.
PMID: 35211638
Free PMC article.
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Low cross reactivity between wild type and deamidated AAV can lead to false negative results in immune monitoring T-cell assays.
Bing SJ, Warrington S, Mazor R.
Bing SJ, et al.
Front Immunol. 2023 Jul 4;14:1211529. doi: 10.3389/fimmu.2023.1211529. eCollection 2023.
Front Immunol. 2023.
PMID: 37469509
Free PMC article.
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