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Hyper-physiologic mechanical cues, as an osteoarthritis disease-relevant environmental perturbation, cause a critical shift in set points of methylation at transcriptionally active CpG sites in neo-cartilage organoids.
Clin Epigenetics. 2024 May 10;16(1):64. doi: 10.1186/s13148-024-01676-0.
Clin Epigenetics. 2024.
PMID: 38730337
Free PMC article.
Hyper-physiologic mechanical cues, as an osteoarthritis disease relevant environmental perturbation, cause a critical shift in set-points of methylation at transcriptionally active CpG sites in neo-cartilage organoids.
Bloks NG, Dicks A, Harissa Z, Nelissen RG, Hajmousa G, Ramos YF, Almeida RC, Guilak F, Meulenbelt I.
Bloks NG, et al.
Res Sq [Preprint]. 2023 Nov 15:rs.3.rs-3568544. doi: 10.21203/rs.3.rs-3568544/v1.
Res Sq. 2023.
PMID: 38014245
Free PMC article.
Updated.
Preprint.
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CCN4/WISP1 Promotes Migration of Human Primary Osteoarthritic Chondrocytes.
Timmermans RGM, Blom AB, Bloks NGC, Nelissen RGHH, van der Linden EHMJ, van der Kraan PM, Meulenbelt I, Ramos YFM, van den Bosch MHJ.
Timmermans RGM, et al. Among authors: bloks ngc.
Cartilage. 2023 Mar;14(1):67-75. doi: 10.1177/19476035221144747. Epub 2022 Dec 22.
Cartilage. 2023.
PMID: 36546648
Free PMC article.
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A human in vitro 3D neo-cartilage model to explore the response of OA risk genes to hyper-physiological mechanical stress.
Timmermans RGM, Bloks NGC, Tuerlings M, van Hoolwerff M, Nelissen RGHH, van der Wal RJP, van der Kraan PM, Blom AB, van den Bosch MHJ, Ramos YFM, Meulenbelt I.
Timmermans RGM, et al. Among authors: bloks ngc.
Osteoarthr Cartil Open. 2021 Dec 25;4(1):100231. doi: 10.1016/j.ocarto.2021.100231. eCollection 2022 Mar.
Osteoarthr Cartil Open. 2021.
PMID: 36474468
Free PMC article.
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Fluid shear stress-induced mechanotransduction in myoblasts: Does it depend on the glycocalyx?
Haroon M, Bloks NGC, Deldicque L, Koppo K, Seddiqi H, Bakker AD, Klein-Nulend J, Jaspers RT.
Haroon M, et al. Among authors: bloks ngc.
Exp Cell Res. 2022 Aug 1;417(1):113204. doi: 10.1016/j.yexcr.2022.113204. Epub 2022 May 16.
Exp Cell Res. 2022.
PMID: 35588795
Free article.
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Reduced growth rate of aged muscle stem cells is associated with impaired mechanosensitivity.
Haroon M, Boers HE, Bakker AD, Bloks NGC, Hoogaars WMH, Giordani L, Musters RJP, Deldicque L, Koppo K, Le Grand F, Klein-Nulend J, Jaspers RT.
Haroon M, et al. Among authors: bloks ngc.
Aging (Albany NY). 2022 Jan 13;14(1):28-53. doi: 10.18632/aging.203830. Epub 2022 Jan 13.
Aging (Albany NY). 2022.
PMID: 35023852
Free PMC article.
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