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Hyper-physiologic mechanical cues, as an osteoarthritis disease relevant environmental perturbation, cause a critical shift in set-points of methylation at transcriptionally active CpG sites in neo-cartilage organoids.
Bloks NG, Dicks A, Harissa Z, Nelissen RG, Hajmousa G, Ramos YF, Almeida RC, Guilak F, Meulenbelt I. Bloks NG, et al. Among authors: nelissen rg. Res Sq [Preprint]. 2023 Nov 15:rs.3.rs-3568544. doi: 10.21203/rs.3.rs-3568544/v1. Res Sq. 2023. PMID: 38014245 Free PMC article. Updated. Preprint.
Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues.
Bos SD, Bovée JV, Duijnisveld BJ, Raine EV, van Dalen WJ, Ramos YF, van der Breggen R, Nelissen RG, Slagboom PE, Loughlin J, Meulenbelt I. Bos SD, et al. Among authors: nelissen rg. Ann Rheum Dis. 2012 Jul;71(7):1254-8. doi: 10.1136/annrheumdis-2011-200981. Epub 2012 Apr 4. Ann Rheum Dis. 2012. PMID: 22492780
Relationship between the functional exon 3 deleted growth hormone receptor polymorphism and symptomatic osteoarthritis in women.
Claessen KM, Kloppenburg M, Kroon HM, Bijsterbosch J, Pereira AM, Romijn JA, van der Straaten T, Nelissen RG, Hofman A, Uitterlinden AG, Duijnisveld BJ, Lakenberg N, Beekman M, van Meurs JB, Slagboom PE, Biermasz NR, Meulenbelt I. Claessen KM, et al. Among authors: nelissen rg. Ann Rheum Dis. 2014 Feb;73(2):433-6. doi: 10.1136/annrheumdis-2012-202713. Epub 2013 Jun 5. Ann Rheum Dis. 2014. PMID: 23740230
A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.
Evangelou E, Kerkhof HJ, Styrkarsdottir U, Ntzani EE, Bos SD, Esko T, Evans DS, Metrustry S, Panoutsopoulou K, Ramos YF, Thorleifsson G, Tsilidis KK; arcOGEN Consortium; Arden N, Aslam N, Bellamy N, Birrell F, Blanco FJ, Carr A, Chapman K, Day-Williams AG, Deloukas P, Doherty M, Engström G, Helgadottir HT, Hofman A, Ingvarsson T, Jonsson H, Keis A, Keurentjes JC, Kloppenburg M, Lind PA, McCaskie A, Martin NG, Milani L, Montgomery GW, Nelissen RG, Nevitt MC, Nilsson PM, Ollier WE, Parimi N, Rai A, Ralston SH, Reed MR, Riancho JA, Rivadeneira F, Rodriguez-Fontenla C, Southam L, Thorsteinsdottir U, Tsezou A, Wallis GA, Wilkinson JM, Gonzalez A, Lane NE, Lohmander LS, Loughlin J, Metspalu A, Uitterlinden AG, Jonsdottir I, Stefansson K, Slagboom PE, Zeggini E, Meulenbelt I, Ioannidis JP, Spector TD, van Meurs JB, Valdes AM. Evangelou E, et al. Among authors: nelissen rg. Ann Rheum Dis. 2014 Dec;73(12):2130-6. doi: 10.1136/annrheumdis-2012-203114. Epub 2013 Aug 29. Ann Rheum Dis. 2014. PMID: 23989986 Free PMC article. Review.
Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis.
Bomer N, den Hollander W, Ramos YF, Bos SD, van der Breggen R, Lakenberg N, Pepers BA, van Eeden AE, Darvishan A, Tobi EW, Duijnisveld BJ, van den Akker EB, Heijmans BT, van Roon-Mom WM, Verbeek FJ, van Osch GJ, Nelissen RG, Slagboom PE, Meulenbelt I. Bomer N, et al. Among authors: nelissen rg. Ann Rheum Dis. 2015 Aug;74(8):1571-9. doi: 10.1136/annrheumdis-2013-204739. Epub 2014 Apr 2. Ann Rheum Dis. 2015. PMID: 24695009 Free PMC article.
Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31.
Styrkarsdottir U, Thorleifsson G, Helgadottir HT, Bomer N, Metrustry S, Bierma-Zeinstra S, Strijbosch AM, Evangelou E, Hart D, Beekman M, Jonasdottir A, Sigurdsson A, Eiriksson FF, Thorsteinsdottir M, Frigge ML, Kong A, Gudjonsson SA, Magnusson OT, Masson G; TREAT-OA Consortium; arcOGEN Consortium; Hofman A, Arden NK, Ingvarsson T, Lohmander S, Kloppenburg M, Rivadeneira F, Nelissen RG, Spector T, Uitterlinden A, Slagboom PE, Thorsteinsdottir U, Jonsdottir I, Valdes AM, Meulenbelt I, van Meurs J, Jonsson H, Stefansson K. Styrkarsdottir U, et al. Among authors: nelissen rg. Nat Genet. 2014 May;46(5):498-502. doi: 10.1038/ng.2957. Epub 2014 Apr 13. Nat Genet. 2014. PMID: 24728293
Genes involved in the osteoarthritis process identified through genome wide expression analysis in articular cartilage; the RAAK study.
Ramos YF, den Hollander W, Bovée JV, Bomer N, van der Breggen R, Lakenberg N, Keurentjes JC, Goeman JJ, Slagboom PE, Nelissen RG, Bos SD, Meulenbelt I. Ramos YF, et al. Among authors: nelissen rg. PLoS One. 2014 Jul 23;9(7):e103056. doi: 10.1371/journal.pone.0103056. eCollection 2014. PLoS One. 2014. PMID: 25054223 Free PMC article.
Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches.
den Hollander W, Ramos YF, Bos SD, Bomer N, van der Breggen R, Lakenberg N, de Dijcker WJ, Duijnisveld BJ, Slagboom PE, Nelissen RG, Meulenbelt I. den Hollander W, et al. Among authors: nelissen rg. Ann Rheum Dis. 2014 Dec;73(12):2208-12. doi: 10.1136/annrheumdis-2014-205980. Epub 2014 Sep 26. Ann Rheum Dis. 2014. PMID: 25261579
Transcriptional associations of osteoarthritis-mediated loss of epigenetic control in articular cartilage.
den Hollander W, Ramos YF, Bomer N, Elzinga S, van der Breggen R, Lakenberg N, de Dijcker WJ, Suchiman HE, Duijnisveld BJ, Houwing-Duistermaat JJ, Slagboom PE, Bos SD, Nelissen RG, Meulenbelt I. den Hollander W, et al. Among authors: nelissen rg. Arthritis Rheumatol. 2015 May;67(8):2108-16. doi: 10.1002/art.39162. Arthritis Rheumatol. 2015. PMID: 25892573
496 results