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Molecular and functional correction of a deep intronic splicing mutation in CFTR by CRISPR-Cas9 gene editing.
Walker AJ, Graham C, Greenwood M, Woodall M, Maeshima R, O'Hara-Wright M, Sanz DJ, Guerrini I, Aldossary AM, O'Callaghan C, Baines DL, Harrison PT, Hart SL. Walker AJ, et al. Among authors: harrison pt. Mol Ther Methods Clin Dev. 2023 Oct 18;31:101140. doi: 10.1016/j.omtm.2023.101140. eCollection 2023 Dec 14. Mol Ther Methods Clin Dev. 2023. PMID: 38027060 Free PMC article.
Genetic therapies for cystic fibrosis lung disease.
Hart SL, Harrison PT. Hart SL, et al. Among authors: harrison pt. Curr Opin Pharmacol. 2017 Jun;34:119-124. doi: 10.1016/j.coph.2017.10.006. Epub 2017 Nov 5. Curr Opin Pharmacol. 2017. PMID: 29107808 Review.
A beginner's guide to gene editing.
Harrison PT, Hart S. Harrison PT, et al. Exp Physiol. 2018 Apr 1;103(4):439-448. doi: 10.1113/EP086047. Epub 2018 Jan 25. Exp Physiol. 2018. PMID: 29282799 Free article. Review.
Gene editing and gene regulation with CRISPR.
Harrison P, Hart S. Harrison P, et al. Exp Physiol. 2018 Apr 1;103(4):437-438. doi: 10.1113/EP086864. Exp Physiol. 2018. PMID: 29603460 Free article. No abstract available.
Use of adenine base editing and homology-independent targeted integration strategies to correct the cystic fibrosis causing variant, W1282X.
Mention K, Cavusoglu-Doran K, Joynt AT, Santos L, Sanz D, Eastman AC, Merlo C, Langfelder-Schwind E, Scallan MF, Farinha CM, Cutting GR, Sharma N, Harrison PT. Mention K, et al. Among authors: harrison pt. Hum Mol Genet. 2023 Nov 17;32(23):3237-3248. doi: 10.1093/hmg/ddad143. Hum Mol Genet. 2023. PMID: 37649273 Free PMC article.
88 results