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Early life adversity shapes social subordination and cell type-specific transcriptomic patterning in the ventral hippocampus.
Kos A, Lopez JP, Bordes J, de Donno C, Dine J, Brivio E, Karamihalev S, Luecken MD, Almeida-Correa S, Gasperoni S, Dick A, Miranda L, Büttner M, Stoffel R, Flachskamm C, Theis FJ, Schmidt MV, Chen A. Kos A, et al. Among authors: luecken md. Sci Adv. 2023 Dec;9(48):eadj3793. doi: 10.1126/sciadv.adj3793. Epub 2023 Dec 1. Sci Adv. 2023. PMID: 38039370 Free PMC article.
Mapping single-cell data to reference atlases by transfer learning.
Lotfollahi M, Naghipourfar M, Luecken MD, Khajavi M, Büttner M, Wagenstetter M, Avsec Ž, Gayoso A, Yosef N, Interlandi M, Rybakov S, Misharin AV, Theis FJ. Lotfollahi M, et al. Among authors: luecken md. Nat Biotechnol. 2022 Jan;40(1):121-130. doi: 10.1038/s41587-021-01001-7. Epub 2021 Aug 30. Nat Biotechnol. 2022. PMID: 34462589 Free PMC article.
Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice.
Aliluev A, Tritschler S, Sterr M, Oppenländer L, Hinterdobler J, Greisle T, Irmler M, Beckers J, Sun N, Walch A, Stemmer K, Kindt A, Krumsiek J, Tschöp MH, Luecken MD, Theis FJ, Lickert H, Böttcher A. Aliluev A, et al. Among authors: luecken md. Nat Metab. 2021 Sep;3(9):1202-1216. doi: 10.1038/s42255-021-00458-9. Epub 2021 Sep 22. Nat Metab. 2021. PMID: 34552271 Free PMC article.
Benchmarking atlas-level data integration in single-cell genomics.
Luecken MD, Büttner M, Chaichoompu K, Danese A, Interlandi M, Mueller MF, Strobl DC, Zappia L, Dugas M, Colomé-Tatché M, Theis FJ. Luecken MD, et al. Nat Methods. 2022 Jan;19(1):41-50. doi: 10.1038/s41592-021-01336-8. Epub 2021 Dec 23. Nat Methods. 2022. PMID: 34949812 Free PMC article.
Parkinson's disease motor symptoms rescue by CRISPRa-reprogramming astrocytes into GABAergic neurons.
Giehrl-Schwab J, Giesert F, Rauser B, Lao CL, Hembach S, Lefort S, Ibarra IL, Koupourtidou C, Luecken MD, Truong DJ, Fischer-Sternjak J, Masserdotti G, Prakash N, Ninkovic J, Hölter SM, Vogt Weisenhorn DM, Theis FJ, Götz M, Wurst W. Giehrl-Schwab J, et al. Among authors: luecken md. EMBO Mol Med. 2022 May 9;14(5):e14797. doi: 10.15252/emmm.202114797. Epub 2022 Apr 4. EMBO Mol Med. 2022. PMID: 35373464 Free PMC article.
Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's disease.
Schmidt S, Luecken MD, Trümbach D, Hembach S, Niedermeier KM, Wenck N, Pflügler K, Stautner C, Böttcher A, Lickert H, Ramirez-Suastegui C, Ahmad R, Ziller MJ, Fitzgerald JC, Ruf V, van de Berg WDJ, Jonker AJ, Gasser T, Winner B, Winkler J, Vogt Weisenhorn DM, Giesert F, Theis FJ, Wurst W. Schmidt S, et al. Among authors: luecken md. Nat Commun. 2022 Aug 16;13(1):4819. doi: 10.1038/s41467-022-32229-9. Nat Commun. 2022. PMID: 35974013 Free PMC article.
The scverse project provides a computational ecosystem for single-cell omics data analysis.
Virshup I, Bredikhin D, Heumos L, Palla G, Sturm G, Gayoso A, Kats I, Koutrouli M; Scverse Community; Berger B, Pe'er D, Regev A, Teichmann SA, Finotello F, Wolf FA, Yosef N, Stegle O, Theis FJ. Virshup I, et al. Nat Biotechnol. 2023 May;41(5):604-606. doi: 10.1038/s41587-023-01733-8. Nat Biotechnol. 2023. PMID: 37037904 No abstract available.
An integrated cell atlas of the lung in health and disease.
Sikkema L, Ramírez-Suástegui C, Strobl DC, Gillett TE, Zappia L, Madissoon E, Markov NS, Zaragosi LE, Ji Y, Ansari M, Arguel MJ, Apperloo L, Banchero M, Bécavin C, Berg M, Chichelnitskiy E, Chung MI, Collin A, Gay ACA, Gote-Schniering J, Hooshiar Kashani B, Inecik K, Jain M, Kapellos TS, Kole TM, Leroy S, Mayr CH, Oliver AJ, von Papen M, Peter L, Taylor CJ, Walzthoeni T, Xu C, Bui LT, De Donno C, Dony L, Faiz A, Guo M, Gutierrez AJ, Heumos L, Huang N, Ibarra IL, Jackson ND, Kadur Lakshminarasimha Murthy P, Lotfollahi M, Tabib T, Talavera-López C, Travaglini KJ, Wilbrey-Clark A, Worlock KB, Yoshida M; Lung Biological Network Consortium; van den Berge M, Bossé Y, Desai TJ, Eickelberg O, Kaminski N, Krasnow MA, Lafyatis R, Nikolic MZ, Powell JE, Rajagopal J, Rojas M, Rozenblatt-Rosen O, Seibold MA, Sheppard D, Shepherd DP, Sin DD, Timens W, Tsankov AM, Whitsett J, Xu Y, Banovich NE, Barbry P, Duong TE, Falk CS, Meyer KB, Kropski JA, Pe'er D, Schiller HB, Tata PR, Schultze JL, Teichmann SA, Misharin AV, Nawijn MC, Luecken MD, Theis FJ. Sikkema L, et al. Among authors: luecken md. Nat Med. 2023 Jun;29(6):1563-1577. doi: 10.1038/s41591-023-02327-2. Epub 2023 Jun 8. Nat Med. 2023. PMID: 37291214 Free PMC article.
21 results