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RNA binding proteins PTBP1 and HNRNPL regulate CFTR mRNA decay.
Siddiqui A, Saxena A, Echols J, Havasi V, Fu L, Keeling KM. Siddiqui A, et al. Among authors: fu l. Heliyon. 2023 Nov 13;9(11):e22281. doi: 10.1016/j.heliyon.2023.e22281. eCollection 2023 Nov. Heliyon. 2023. PMID: 38045134 Free PMC article.
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion.
Sharma J, Du M, Wong E, Mutyam V, Li Y, Chen J, Wangen J, Thrasher K, Fu L, Peng N, Tang L, Liu K, Mathew B, Bostwick RJ, Augelli-Szafran CE, Bihler H, Liang F, Mahiou J, Saltz J, Rab A, Hong J, Sorscher EJ, Mendenhall EM, Coppola CJ, Keeling KM, Green R, Mense M, Suto MJ, Rowe SM, Bedwell DM. Sharma J, et al. Among authors: fu l. Nat Commun. 2021 Jul 16;12(1):4358. doi: 10.1038/s41467-021-24575-x. Nat Commun. 2021. PMID: 34272367 Free PMC article.
The synthetic aminoglycoside ELX-02 induces readthrough of G550X-CFTR producing superfunctional protein that can be further enhanced by CFTR modulators.
Chen J, Thrasher K, Fu L, Wang W, Aghamohammadzadeh S, Wen H, Tang L, Keeling KM, Falk Libby E, Bedwell DM, Rowe SM. Chen J, et al. Among authors: fu l. Am J Physiol Lung Cell Mol Physiol. 2023 Jun 1;324(6):L756-L770. doi: 10.1152/ajplung.00038.2023. Epub 2023 Apr 4. Am J Physiol Lung Cell Mol Physiol. 2023. PMID: 37014818 Free PMC article.
CFTR expression regulation by the unfolded protein response.
Bartoszewski R, Rab A, Fu L, Bartoszewska S, Collawn J, Bebok Z. Bartoszewski R, et al. Among authors: fu l. Methods Enzymol. 2011;491:3-24. doi: 10.1016/B978-0-12-385928-0.00001-8. Methods Enzymol. 2011. PMID: 21329791 Free PMC article.
8,078 results