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N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting.
Mulroney TE, Pöyry T, Yam-Puc JC, Rust M, Harvey RF, Kalmar L, Horner E, Booth L, Ferreira AP, Stoneley M, Sawarkar R, Mentzer AJ, Lilley KS, Smales CM, von der Haar T, Turtle L, Dunachie S, Klenerman P, Thaventhiran JED, Willis AE. Mulroney TE, et al. Among authors: smales cm. Nature. 2024 Jan;625(7993):189-194. doi: 10.1038/s41586-023-06800-3. Epub 2023 Dec 6. Nature. 2024. PMID: 38057663 Free PMC article.
Translation of in vitro-transcribed RNA therapeutics.
von der Haar T, Mulroney TE, Hedayioglu F, Kurusamy S, Rust M, Lilley KS, Thaventhiran JE, Willis AE, Smales CM. von der Haar T, et al. Among authors: smales cm. Front Mol Biosci. 2023 Feb 8;10:1128067. doi: 10.3389/fmolb.2023.1128067. eCollection 2023. Front Mol Biosci. 2023. PMID: 36845540 Free PMC article. Review.
Control of translation elongation in health and disease.
Knight JRP, Garland G, Pöyry T, Mead E, Vlahov N, Sfakianos A, Grosso S, De-Lima-Hedayioglu F, Mallucci GR, von der Haar T, Smales CM, Sansom OJ, Willis AE. Knight JRP, et al. Among authors: smales cm. Dis Model Mech. 2020 Mar 26;13(3):dmm043208. doi: 10.1242/dmm.043208. Dis Model Mech. 2020. PMID: 32298235 Free PMC article. Review.
Control and regulation of mRNA translation.
Mead EJ, Masterton RJ, von der Haar T, Tuite MF, Smales CM. Mead EJ, et al. Among authors: smales cm. Biochem Soc Trans. 2014 Feb;42(1):151-4. doi: 10.1042/BST20130259. Biochem Soc Trans. 2014. PMID: 24450643
Engineered transient and stable overexpression of translation factors eIF3i and eIF3c in CHOK1 and HEK293 cells gives enhanced cell growth associated with increased c-Myc expression and increased recombinant protein synthesis.
Roobol A, Roobol J, Smith ME, Carden MJ, Hershey JWB, Willis AE, Smales CM. Roobol A, et al. Among authors: smales cm. Metab Eng. 2020 May;59:98-105. doi: 10.1016/j.ymben.2020.02.001. Epub 2020 Feb 13. Metab Eng. 2020. PMID: 32061967 Free PMC article.
108 results