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Biosynthesis of Haloterpenoids in Red Algae via Microbial-like Type I Terpene Synthases.
Steele TS, Burkhardt I, Moore ML, de Rond T, Bone HK, Barry K, Bunting VM, Grimwood J, Handley LH, Rajasekar S, Talag J, Michael TP, Moore BS. Steele TS, et al. Among authors: de rond t. ACS Chem Biol. 2024 Jan 19;19(1):185-192. doi: 10.1021/acschembio.3c00627. Epub 2023 Dec 11. ACS Chem Biol. 2024. PMID: 38081799 Free PMC article.
Artificial intelligence for natural product drug discovery.
Mullowney MW, Duncan KR, Elsayed SS, Garg N, van der Hooft JJJ, Martin NI, Meijer D, Terlouw BR, Biermann F, Blin K, Durairaj J, Gorostiola González M, Helfrich EJN, Huber F, Leopold-Messer S, Rajan K, de Rond T, van Santen JA, Sorokina M, Balunas MJ, Beniddir MA, van Bergeijk DA, Carroll LM, Clark CM, Clevert DA, Dejong CA, Du C, Ferrinho S, Grisoni F, Hofstetter A, Jespers W, Kalinina OV, Kautsar SA, Kim H, Leao TF, Masschelein J, Rees ER, Reher R, Reker D, Schwaller P, Segler M, Skinnider MA, Walker AS, Willighagen EL, Zdrazil B, Ziemert N, Goss RJM, Guyomard P, Volkamer A, Gerwick WH, Kim HU, Müller R, van Wezel GP, van Westen GJP, Hirsch AKH, Linington RG, Robinson SL, Medema MH. Mullowney MW, et al. Among authors: de rond t. Nat Rev Drug Discov. 2023 Nov;22(11):895-916. doi: 10.1038/s41573-023-00774-7. Epub 2023 Sep 11. Nat Rev Drug Discov. 2023. PMID: 37697042 Review.
Terpene biosynthesis in marine sponge animals.
Wilson K, de Rond T, Burkhardt I, Steele TS, Schäfer RJB, Podell S, Allen EE, Moore BS. Wilson K, et al. Among authors: de rond t. Proc Natl Acad Sci U S A. 2023 Feb 28;120(9):e2220934120. doi: 10.1073/pnas.2220934120. Epub 2023 Feb 21. Proc Natl Acad Sci U S A. 2023. PMID: 36802428 Free PMC article.
Ancient plant-like terpene biosynthesis in corals.
Burkhardt I, de Rond T, Chen PY, Moore BS. Burkhardt I, et al. Among authors: de rond t. Nat Chem Biol. 2022 Jun;18(6):664-669. doi: 10.1038/s41589-022-01026-2. Epub 2022 May 23. Nat Chem Biol. 2022. PMID: 35606558 Free PMC article.
Mining genomes to illuminate the specialized chemistry of life.
Medema MH, de Rond T, Moore BS. Medema MH, et al. Among authors: de rond t. Nat Rev Genet. 2021 Sep;22(9):553-571. doi: 10.1038/s41576-021-00363-7. Epub 2021 Jun 3. Nat Rev Genet. 2021. PMID: 34083778 Free PMC article. Review.
A community resource for paired genomic and metabolomic data mining.
Schorn MA, Verhoeven S, Ridder L, Huber F, Acharya DD, Aksenov AA, Aleti G, Moghaddam JA, Aron AT, Aziz S, Bauermeister A, Bauman KD, Baunach M, Beemelmanns C, Beman JM, Berlanga-Clavero MV, Blacutt AA, Bode HB, Boullie A, Brejnrod A, Bugni TS, Calteau A, Cao L, Carrión VJ, Castelo-Branco R, Chanana S, Chase AB, Chevrette MG, Costa-Lotufo LV, Crawford JM, Currie CR, Cuypers B, Dang T, de Rond T, Demko AM, Dittmann E, Du C, Drozd C, Dujardin JC, Dutton RJ, Edlund A, Fewer DP, Garg N, Gauglitz JM, Gentry EC, Gerwick L, Glukhov E, Gross H, Gugger M, Guillén Matus DG, Helfrich EJN, Hempel BF, Hur JS, Iorio M, Jensen PR, Kang KB, Kaysser L, Kelleher NL, Kim CS, Kim KH, Koester I, König GM, Leao T, Lee SR, Lee YY, Li X, Little JC, Maloney KN, Männle D, Martin H C, McAvoy AC, Metcalf WW, Mohimani H, Molina-Santiago C, Moore BS, Mullowney MW, Muskat M, Nothias LF, O'Neill EC, Parkinson EI, Petras D, Piel J, Pierce EC, Pires K, Reher R, Romero D, Roper MC, Rust M, Saad H, Saenz C, Sanchez LM, Sørensen SJ, Sosio M, Süssmuth RD, Sweeney D, Tahlan K, Thomson RJ, Tobias NJ, Trindade-Silva AE, van Wezel GP, Wang M, Weldon KC, Zhang F, Ziemert N, Duncan KR, Crüsemann M, Rogers S, Dorreste… See abstract for full author list ➔ Schorn MA, et al. Among authors: de rond t. Nat Chem Biol. 2021 Apr;17(4):363-368. doi: 10.1038/s41589-020-00724-z. Nat Chem Biol. 2021. PMID: 33589842 Free PMC article.
Mevalonate Pathway Promiscuity Enables Noncanonical Terpene Production.
Eiben CB, de Rond T, Bloszies C, Gin J, Chiniquy J, Baidoo EEK, Petzold CJ, Hillson NJ, Fiehn O, Keasling JD. Eiben CB, et al. Among authors: de rond t. ACS Synth Biol. 2019 Oct 18;8(10):2238-2247. doi: 10.1021/acssynbio.9b00230. Epub 2019 Oct 2. ACS Synth Biol. 2019. PMID: 31576747
23 results