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On the benefits of the tryptophan metabolite 3-hydroxyanthranilic acid in Caenorhabditis elegans and mouse aging.
Dang H, Castro-Portuguez R, Espejo L, Backer G, Freitas S, Spence E, Meyers J, Shuck K, Gardea EA, Chang LM, Balsa J, Thorns N, Corban C, Liu T, Bean S, Sheehan S, Korstanje R, Sutphin GL. Dang H, et al. Among authors: sutphin gl. Nat Commun. 2023 Dec 14;14(1):8338. doi: 10.1038/s41467-023-43527-1. Nat Commun. 2023. PMID: 38097593 Free PMC article.
The transcriptional landscape of age in human peripheral blood.
Peters MJ, Joehanes R, Pilling LC, Schurmann C, Conneely KN, Powell J, Reinmaa E, Sutphin GL, Zhernakova A, Schramm K, Wilson YA, Kobes S, Tukiainen T; NABEC/UKBEC Consortium; Ramos YF, Göring HH, Fornage M, Liu Y, Gharib SA, Stranger BE, De Jager PL, Aviv A, Levy D, Murabito JM, Munson PJ, Huan T, Hofman A, Uitterlinden AG, Rivadeneira F, van Rooij J, Stolk L, Broer L, Verbiest MM, Jhamai M, Arp P, Metspalu A, Tserel L, Milani L, Samani NJ, Peterson P, Kasela S, Codd V, Peters A, Ward-Caviness CK, Herder C, Waldenberger M, Roden M, Singmann P, Zeilinger S, Illig T, Homuth G, Grabe HJ, Völzke H, Steil L, Kocher T, Murray A, Melzer D, Yaghootkar H, Bandinelli S, Moses EK, Kent JW, Curran JE, Johnson MP, Williams-Blangero S, Westra HJ, McRae AF, Smith JA, Kardia SL, Hovatta I, Perola M, Ripatti S, Salomaa V, Henders AK, Martin NG, Smith AK, Mehta D, Binder EB, Nylocks KM, Kennedy EM, Klengel T, Ding J, Suchy-Dicey AM, Enquobahrie DA, Brody J, Rotter JI, Chen YD, Houwing-Duistermaat J, Kloppenburg M, Slagboom PE, Helmer Q, den Hollander W, Bean S, Raj T, Bakhshi N, Wang QP, Oyston LJ, Psaty BM, Tracy RP, Montgomery GW, Turner ST, Blangero J, Meulenbelt I, Ressler KJ, Yang J, F… See abstract for full author list ➔ Peters MJ, et al. Among authors: sutphin gl. Nat Commun. 2015 Oct 22;6:8570. doi: 10.1038/ncomms9570. Nat Commun. 2015. PMID: 26490707 Free PMC article.
Caenorhabditis elegans orthologs of human genes differentially expressed with age are enriched for determinants of longevity.
Sutphin GL, Backer G, Sheehan S, Bean S, Corban C, Liu T, Peters MJ, van Meurs JBJ, Murabito JM, Johnson AD, Korstanje R; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Gene Expression Working Group. Sutphin GL, et al. Aging Cell. 2017 Aug;16(4):672-682. doi: 10.1111/acel.12595. Epub 2017 Apr 12. Aging Cell. 2017. PMID: 28401650 Free PMC article.
The Emerging Role of 3-Hydroxyanthranilic Acid on C. elegans Aging Immune Function.
Espejo LS, DeNicola D, Chang LM, Hofschneider V, Haskins AE, Balsa J, Freitas SS, Antenor A, Hamming S, Hull B, Castro-Portuguez R, Dang H, Sutphin GL. Espejo LS, et al. Among authors: sutphin gl. bioRxiv [Preprint]. 2024 Jan 9:2024.01.07.574394. doi: 10.1101/2024.01.07.574394. bioRxiv. 2024. PMID: 38260592 Free PMC article. Preprint.
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