Bunch L - Search Results

1

Synthesis and pharmacological characterization of conformationally restricted 2-amino-Adipic acid analogs and carboxycyclopropyl glycines as selective metabotropic glutamate 2 receptor agonists.

Staudt M, Liu N, Malhaire F, Doroudian Y, Prézeau L, Renard E, Hasanpour Z, Pin JP, Bunch L. Staudt M, et al. Among authors: bunch l. Eur J Med Chem. 2024 Feb 15;266:116157. doi: 10.1016/j.ejmech.2024.116157. Epub 2024 Jan 18. Eur J Med Chem. 2024. PMID: 38245976 Free article.

2

Design, Synthesis, Pharmacology, and In Silico Studies of (1S,2S,3S)-2-((S)-Amino(carboxy)methyl)-3-(carboxymethyl)cyclopropane-1-carboxylic Acid (LBG30300): A Picomolar Potency Subtype-Selective mGlu₂ Receptor Agonist.

Liu N, Eshak F, Malhaire F, Brabet I, Prézeau L, Renard E, Pin JP, Acher FC, Staudt M, Bunch L. Liu N, et al. Among authors: bunch l. J Med Chem. 2024 Jan 25;67(2):1314-1326. doi: 10.1021/acs.jmedchem.3c01811. Epub 2024 Jan 3. J Med Chem. 2024. PMID: 38170918

3

Careful Considerations for Midcrisis Consent to and Refusal of Blood Products.

Hester DM, Bunch L. Hester DM, et al. Among authors: bunch l. Anesth Analg. 2024 Jan 1;138(1):85-88. doi: 10.1213/ANE.0000000000006704. Epub 2023 Dec 15. Anesth Analg. 2024. PMID: 38100801 No abstract available.

4

Some Treatments Over Objection, Not Others, Are Ethically Justifiable When Managing Anorexia Nervosa.

Bunch L. Bunch L. Am J Bioeth. 2023 Aug;23(8):99-101. doi: 10.1080/15265161.2023.2217119. Am J Bioeth. 2023. PMID: 37450539 No abstract available.

5

Discovery of (R)-2-amino-3-triazolpropanoic acid derivatives as NMDA receptor glycine site agonists with GluN2 subunit-specific activity.

Zhao F, Mazis G, Yi F, Lotti JS, Layeux MS, Schultz EP, Bunch L, Hansen KB, Clausen RP. Zhao F, et al. Among authors: bunch l. Front Chem. 2022 Nov 17;10:1008233. doi: 10.3389/fchem.2022.1008233. eCollection 2022. Front Chem. 2022. PMID: 36465862 Free PMC article.

6

In vitro ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs.

Bechthold E, Grey L, Diamant E, Schmidt J, Steigerwald R, Zhao F, Hansen KB, Bunch L, Clausen RP, Wünsch B. Bechthold E, et al. Among authors: bunch l. Biol Chem. 2022 Nov 25;404(4):255-265. doi: 10.1515/hsz-2022-0229. Print 2023 Mar 28. Biol Chem. 2022. PMID: 36427206 Free PMC article.

7

(S)-2-Mercaptohistidine: A First Selective Orthosteric GluK3 Antagonist.

Poulie CBM, Larsen Y, Leteneur C, Barthet G, Bjørn-Yoshimoto WE, Malhaire F, Nielsen B, Pin JP, Mulle C, Pickering DS, Bunch L. Poulie CBM, et al. Among authors: bunch l. ACS Chem Neurosci. 2022 May 18;13(10):1580-1587. doi: 10.1021/acschemneuro.2c00162. Epub 2022 Apr 27. ACS Chem Neurosci. 2022. PMID: 35475632

8

Transition Metal-Free Synthesis of meta-Bromo- and meta-Trifluoromethylanilines from Cyclopentanones by a Cascade Reaction.

Staudt M, Cetin A, Bunch L. Staudt M, et al. Among authors: bunch l. Chemistry. 2022 Feb 21;28(10):e202102998. doi: 10.1002/chem.202102998. Epub 2022 Feb 2. Chemistry. 2022. PMID: 35076996

9

Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity.

Zhao F, Atxabal U, Mariottini S, Yi F, Lotti JS, Rouzbeh N, Liu N, Bunch L, Hansen KB, Clausen RP. Zhao F, et al. Among authors: bunch l. J Med Chem. 2022 Jan 13;65(1):734-746. doi: 10.1021/acs.jmedchem.1c01810. Epub 2021 Dec 17. J Med Chem. 2022. PMID: 34918931 Free PMC article.

10

Synthesis of Polysubstituted Meta-Halophenols by Anion-Accelerated 2π-Electrocyclic Ring Opening.

Staudt M, Sølling T, Bunch L. Staudt M, et al. Among authors: bunch l. Chemistry. 2021 Jul 26;27(42):10941-10947. doi: 10.1002/chem.202100939. Epub 2021 Jun 14. Chemistry. 2021. PMID: 34041800

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