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A distinct human cell type expressing MHCII and RORγt with dual characteristics of dendritic cells and type 3 innate lymphoid cells.
Ulezko Antonova A, Lonardi S, Monti M, Missale F, Fan C, Coates ML, Bugatti M, Jaeger N, Fernandes Rodrigues P, Brioschi S, Trsan T, Fachi JL, Nguyen KM, Nunley RM, Moratto D, Zini S, Kong L, Deguine J, Peeples ME, Xavier RJ, Clatworthy MR, Wang T, Cella M, Vermi W, Colonna M. Ulezko Antonova A, et al. Among authors: xavier rj. Proc Natl Acad Sci U S A. 2023 Dec 26;120(52):e2318710120. doi: 10.1073/pnas.2318710120. Epub 2023 Dec 18. Proc Natl Acad Sci U S A. 2023. PMID: 38109523 Free PMC article.
The landscape of immune dysregulation in Crohn's disease revealed through single-cell transcriptomic profiling in the ileum and colon.
Kong L, Pokatayev V, Lefkovith A, Carter GT, Creasey EA, Krishna C, Subramanian S, Kochar B, Ashenberg O, Lau H, Ananthakrishnan AN, Graham DB, Deguine J, Xavier RJ. Kong L, et al. Among authors: xavier rj. Immunity. 2023 Feb 14;56(2):444-458.e5. doi: 10.1016/j.immuni.2023.01.002. Epub 2023 Jan 30. Immunity. 2023. PMID: 36720220 Free PMC article.
A human model of asthma exacerbation reveals transcriptional programs and cell circuits specific to allergic asthma.
Alladina J, Smith NP, Kooistra T, Slowikowski K, Kernin IJ, Deguine J, Keen HL, Manakongtreecheep K, Tantivit J, Rahimi RA, Sheng SL, Nguyen ND, Haring AM, Giacona FL, Hariri LP, Xavier RJ, Luster AD, Villani AC, Cho JL, Medoff BD. Alladina J, et al. Among authors: xavier rj. Sci Immunol. 2023 May 12;8(83):eabq6352. doi: 10.1126/sciimmunol.abq6352. Epub 2023 May 5. Sci Immunol. 2023. PMID: 37146132 Free PMC article.
Untangling the CD4 T cell response to the microbiota.
Mayassi T, Xavier RJ. Mayassi T, et al. Among authors: xavier rj. Proc Natl Acad Sci U S A. 2023 Apr 18;120(16):e2303351120. doi: 10.1073/pnas.2303351120. Epub 2023 Apr 10. Proc Natl Acad Sci U S A. 2023. PMID: 37036966 Free PMC article. No abstract available.
Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation.
Babbe H, Sundberg TB, Tichenor M, Seierstad M, Bacani G, Berstler J, Chai W, Chang L, Chung M, Coe K, Collins B, Finley M, Guletsky A, Lemke CT, Mak PA, Mathur A, Mercado-Marin EV, Metkar S, Raymond DD, Rives ML, Rizzolio M, Shaffer PL, Smith R, Smith J, Steele R, Steffens H, Suarez J, Tian G, Majewski N, Volak LP, Wei J, Desai PT, Ong LL, Koudriakova T, Goldberg SD, Hirst G, Kaushik VK, Ort T, Seth N, Graham DB, Plevy S, Venable JD, Xavier RJ, Towne JE. Babbe H, et al. Among authors: xavier rj. Proc Natl Acad Sci U S A. 2024 Jan 2;121(1):e2307086120. doi: 10.1073/pnas.2307086120. Epub 2023 Dec 26. Proc Natl Acad Sci U S A. 2024. PMID: 38147543
Collinsella aerofaciens Produces a pH-Responsive Lipid Immunogen.
Kwon J, Bae M, Szamosvári D, Cassilly CD, Bolze AS, Jackson DR, Xavier RJ, Clardy J. Kwon J, et al. Among authors: xavier rj. J Am Chem Soc. 2023 Apr 5;145(13):7071-7074. doi: 10.1021/jacs.3c00250. Epub 2023 Mar 23. J Am Chem Soc. 2023. PMID: 36952265 Free PMC article.
525 results