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Stiffness-induced cancer-associated fibroblasts are responsible for immunosuppression in a platelet-derived growth factor ligand-dependent manner.
Gamradt P, Thierry K, Masmoudi M, Wu Z, Hernandez-Vargas H, Bachy S, Antonio T, Savas B, Hussain Z, Tomasini R, Milani P, Bertolino P, Hennino A. Gamradt P, et al. Among authors: tomasini r. PNAS Nexus. 2023 Dec 18;2(12):pgad405. doi: 10.1093/pnasnexus/pgad405. eCollection 2023 Dec. PNAS Nexus. 2023. PMID: 38111825 Free PMC article.
The conditional expression of KRAS G12D in mouse pancreas induces disorganization of endocrine islets prior the onset of ductal pre-cancerous lesions.
Gout J, Pommier RM, Vincent DF, Ripoche D, Goddard-Léon S, Colombe A, Treilleux I, Valcourt U, Tomasini R, Dufresne M, Bertolino P, Bartholin L. Gout J, et al. Among authors: tomasini r. Pancreatology. 2013 May-Jun;13(3):191-5. doi: 10.1016/j.pan.2013.02.001. Epub 2013 Feb 18. Pancreatology. 2013. PMID: 23719586
Stromal protein βig-h3 reprogrammes tumour microenvironment in pancreatic cancer.
Goehrig D, Nigri J, Samain R, Wu Z, Cappello P, Gabiane G, Zhang X, Zhao Y, Kim IS, Chanal M, Curto R, Hervieu V, de La Fouchardière C, Novelli F, Milani P, Tomasini R, Bousquet C, Bertolino P, Hennino A. Goehrig D, et al. Among authors: tomasini r. Gut. 2019 Apr;68(4):693-707. doi: 10.1136/gutjnl-2018-317570. Epub 2018 Nov 10. Gut. 2019. PMID: 30415234 Free PMC article.
Oncogene-Induced Senescence Limits the Progression of Pancreatic Neoplasia through Production of Activin A.
Zhao Y, Wu Z, Chanal M, Guillaumond F, Goehrig D, Bachy S, Principe M, Ziverec A, Flaman JM, Collin G, Tomasini R, Pasternack A, Ritvos O, Vasseur S, Bernard D, Hennino A, Bertolino P. Zhao Y, et al. Among authors: tomasini r. Cancer Res. 2020 Aug 15;80(16):3359-3371. doi: 10.1158/0008-5472.CAN-19-3763. Epub 2020 Jun 17. Cancer Res. 2020. PMID: 32554750
SK2 channels set a signalling hub bolstering CAF-triggered tumourigenic processes in pancreatic cancer.
Rapetti-Mauss R, Nigri J, Berenguier C, Finetti P, Tubiana SS, Labrum B, Allegrini B, Pellissier B, Efthymiou G, Hussain Z, Bousquet C, Dusetti N, Bertucci F, Guizouarn H, Melnyk P, Borgese F, Tomasini R, Soriani O. Rapetti-Mauss R, et al. Among authors: tomasini r. Gut. 2023 Apr;72(4):722-735. doi: 10.1136/gutjnl-2021-326610. Epub 2022 Sep 1. Gut. 2023. PMID: 36882214
Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated fibroblasts abrogates pancreatic tumour chemoresistance.
Duluc C, Moatassim-Billah S, Chalabi-Dchar M, Perraud A, Samain R, Breibach F, Gayral M, Cordelier P, Delisle MB, Bousquet-Dubouch MP, Tomasini R, Schmid H, Mathonnet M, Pyronnet S, Martineau Y, Bousquet C. Duluc C, et al. Among authors: tomasini r. EMBO Mol Med. 2015 Jun;7(6):735-53. doi: 10.15252/emmm.201404346. EMBO Mol Med. 2015. PMID: 25834145 Free PMC article.
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