Shi L - Search Results

1

Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile.

Okorom AV, Camacho-Hernandez GA, Salomon K, Lee KH, Ku TC, Cao J, Won SJ, Friedman J, Lam J, Paule J, Rais R, Klein B, Xi ZX, Shi L, Loland CJ, Newman AH. Okorom AV, et al. Among authors: shi l. J Med Chem. 2024 Jan 11;67(1):709-727. doi: 10.1021/acs.jmedchem.3c02037. Epub 2023 Dec 20. J Med Chem. 2024. PMID: 38117239

2

An intracellular interaction network regulates conformational transitions in the dopamine transporter.

Kniazeff J, Shi L, Loland CJ, Javitch JA, Weinstein H, Gether U. Kniazeff J, et al. Among authors: shi l. J Biol Chem. 2008 Jun 20;283(25):17691-701. doi: 10.1074/jbc.M800475200. Epub 2008 Apr 21. J Biol Chem. 2008. PMID: 18426798 Free PMC article.

3

The binding sites for cocaine and dopamine in the dopamine transporter overlap.

Beuming T, Kniazeff J, Bergmann ML, Shi L, Gracia L, Raniszewska K, Newman AH, Javitch JA, Weinstein H, Gether U, Loland CJ. Beuming T, et al. Among authors: shi l. Nat Neurosci. 2008 Jul;11(7):780-9. doi: 10.1038/nn.2146. Epub 2008 Jun 22. Nat Neurosci. 2008. PMID: 18568020 Free PMC article.

4

The binding sites for benztropines and dopamine in the dopamine transporter overlap.

Bisgaard H, Larsen MA, Mazier S, Beuming T, Newman AH, Weinstein H, Shi L, Loland CJ, Gether U. Bisgaard H, et al. Among authors: shi l. Neuropharmacology. 2011 Jan;60(1):182-90. doi: 10.1016/j.neuropharm.2010.08.021. Epub 2010 Sep 6. Neuropharmacology. 2011. PMID: 20816875 Free PMC article.

5

R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse.

Loland CJ, Mereu M, Okunola OM, Cao J, Prisinzano TE, Mazier S, Kopajtic T, Shi L, Katz JL, Tanda G, Newman AH. Loland CJ, et al. Among authors: shi l. Biol Psychiatry. 2012 Sep 1;72(5):405-13. doi: 10.1016/j.biopsych.2012.03.022. Epub 2012 Apr 25. Biol Psychiatry. 2012. PMID: 22537794 Free PMC article.

6

Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.

Newman AH, Beuming T, Banala AK, Donthamsetti P, Pongetti K, LaBounty A, Levy B, Cao J, Michino M, Luedtke RR, Javitch JA, Shi L. Newman AH, et al. Among authors: shi l. J Med Chem. 2012 Aug 9;55(15):6689-99. doi: 10.1021/jm300482h. Epub 2012 Jun 7. J Med Chem. 2012. PMID: 22632094 Free PMC article.

7

Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter.

Plenge P, Shi L, Beuming T, Te J, Newman AH, Weinstein H, Gether U, Loland CJ. Plenge P, et al. Among authors: shi l. J Biol Chem. 2012 Nov 16;287(47):39316-26. doi: 10.1074/jbc.M112.371765. Epub 2012 Sep 24. J Biol Chem. 2012. PMID: 23007398 Free PMC article.

8

A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors.

Michino M, Donthamsetti P, Beuming T, Banala A, Duan L, Roux T, Han Y, Trinquet E, Newman AH, Javitch JA, Shi L. Michino M, et al. Among authors: shi l. Mol Pharmacol. 2013 Dec;84(6):854-64. doi: 10.1124/mol.113.087833. Epub 2013 Sep 23. Mol Pharmacol. 2013. PMID: 24061855 Free PMC article.

9

Beyond small-molecule SAR: using the dopamine D3 receptor crystal structure to guide drug design.

Keck TM, Burzynski C, Shi L, Newman AH. Keck TM, et al. Among authors: shi l. Adv Pharmacol. 2014;69:267-300. doi: 10.1016/B978-0-12-420118-7.00007-X. Adv Pharmacol. 2014. PMID: 24484980 Free PMC article. Review.

10

Elucidation of structural elements for selectivity across monoamine transporters: novel 2-[(diphenylmethyl)sulfinyl]acetamide (modafinil) analogues.

Okunola-Bakare OM, Cao J, Kopajtic T, Katz JL, Loland CJ, Shi L, Newman AH. Okunola-Bakare OM, et al. Among authors: shi l. J Med Chem. 2014 Feb 13;57(3):1000-13. doi: 10.1021/jm401754x. Epub 2014 Feb 4. J Med Chem. 2014. PMID: 24494745 Free PMC article.

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