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A dual-targeting succinate dehydrogenase and F1Fo-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosis.
Adolph C, Cheung CY, McNeil MB, Jowsey WJ, Williams ZC, Hards K, Harold LK, Aboelela A, Bujaroski RS, Buckley BJ, Tyndall JDA, Li Z, Langer JD, Preiss L, Meier T, Steyn AJC, Rhee KY, Berney M, Kelso MJ, Cook GM. Adolph C, et al. Among authors: langer jd. Cell Chem Biol. 2024 Apr 18;31(4):683-698.e7. doi: 10.1016/j.chembiol.2023.12.002. Epub 2023 Dec 26. Cell Chem Biol. 2024. PMID: 38151019
Engineering rotor ring stoichiometries in the ATP synthase.
Pogoryelov D, Klyszejko AL, Krasnoselska GO, Heller EM, Leone V, Langer JD, Vonck J, Müller DJ, Faraldo-Gómez JD, Meier T. Pogoryelov D, et al. Among authors: langer jd. Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):E1599-608. doi: 10.1073/pnas.1120027109. Epub 2012 May 24. Proc Natl Acad Sci U S A. 2012. PMID: 22628564 Free PMC article.
An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis.
Hards K, Cheung CY, Waller N, Adolph C, Keighley L, Tee ZS, Harold LK, Menorca A, Bujaroski RS, Buckley BJ, Tyndall JDA, McNeil MB, Rhee KY, Opel-Reading HK, Krause K, Preiss L, Langer JD, Meier T, Hasenoehrl EJ, Berney M, Kelso MJ, Cook GM. Hards K, et al. Among authors: langer jd. Commun Biol. 2022 Feb 24;5(1):166. doi: 10.1038/s42003-022-03110-8. Commun Biol. 2022. PMID: 35210534 Free PMC article.
Top-Down Identification and Sequence Analysis of Small Membrane Proteins Using MALDI-MS/MS.
Meier-Credo J, Preiss L, Wüllenweber I, Resemann A, Nordmann C, Zabret J, Suckau D, Michel H, Nowaczyk MM, Meier T, Langer JD. Meier-Credo J, et al. Among authors: langer jd. J Am Soc Mass Spectrom. 2022 Jul 6;33(7):1293-1302. doi: 10.1021/jasms.2c00102. Epub 2022 Jun 27. J Am Soc Mass Spectrom. 2022. PMID: 35758524 Free PMC article.
MEIS homeodomain proteins facilitate PARP1/ARTD1-mediated eviction of histone H1.
Hau AC, Grebbin BM, Agoston Z, Anders-Maurer M, Müller T, Groß A, Kolb J, Langer JD, Döring C, Schulte D. Hau AC, et al. Among authors: langer jd. J Cell Biol. 2017 Sep 4;216(9):2715-2729. doi: 10.1083/jcb.201701154. Epub 2017 Jul 24. J Cell Biol. 2017. PMID: 28739678 Free PMC article.
76 results