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T-cell stimulating vaccines empower CD3 bispecific antibody therapy in solid tumors.
Middelburg J, Sluijter M, Schaap G, Göynük B, Lloyd K, Ovcinnikovs V, Zom GG, Marijnissen RJ, Groeneveldt C, Griffioen L, Sandker GGW, Heskamp S, van der Burg SH, Arakelian T, Ossendorp F, Arens R, Schuurman J, Kemper K, van Hall T. Middelburg J, et al. Among authors: zom gg. Nat Commun. 2024 Jan 2;15(1):48. doi: 10.1038/s41467-023-44308-6. Nat Commun. 2024. PMID: 38167722 Free PMC article.
Intradermal vaccination of HPV-16 E6 synthetic peptides conjugated to an optimized Toll-like receptor 2 ligand shows safety and potent T cell immunogenicity in patients with HPV-16 positive (pre-)malignant lesions.
Speetjens FM, Welters MJP, Slingerland M, van Poelgeest MIE, de Vos van Steenwijk PJ, Roozen I, Boekestijn S, Loof NM, Zom GG, Valentijn ARPM, Krebber WJ, Meeuwenoord NJ, Janssen CAH, Melief CJM, van der Marel GA, Filippov DV, van der Burg SH, Gelderblom H, Ossendorp F. Speetjens FM, et al. Among authors: zom gg. J Immunother Cancer. 2022 Oct;10(10):e005016. doi: 10.1136/jitc-2022-005016. J Immunother Cancer. 2022. PMID: 36261215 Free PMC article. Clinical Trial.
Logic-gated antibody pairs that selectively act on cells co-expressing two antigens.
Oostindie SC, Rinaldi DA, Zom GG, Wester MJ, Paulet D, Al-Tamimi K, van der Meijden E, Scheick JR, Wilpshaar T, de Jong B, Hoff-van den Broek M, Grattan RM, Oosterhoff JJ, Vignau J, Verploegen S, Boross P, Beurskens FJ, Lidke DS, Schuurman J, de Jong RN. Oostindie SC, et al. Among authors: zom gg. Nat Biotechnol. 2022 Oct;40(10):1509-1519. doi: 10.1038/s41587-022-01384-1. Epub 2022 Jul 25. Nat Biotechnol. 2022. PMID: 35879362 Free PMC article.
Enapotamab vedotin, an AXL-specific antibody-drug conjugate, shows preclinical antitumor activity in non-small cell lung cancer.
Koopman LA, Terp MG, Zom GG, Janmaat ML, Jacobsen K, Gresnigt-van den Heuvel E, Brandhorst M, Forssmann U, de Bree F, Pencheva N, Lingnau A, Zipeto MA, Parren PW, Breij EC, Ditzel HJ. Koopman LA, et al. Among authors: zom gg. JCI Insight. 2019 Nov 1;4(21):e128199. doi: 10.1172/jci.insight.128199. JCI Insight. 2019. PMID: 31600169 Free PMC article.
Lipophilic Muramyl Dipeptide-Antigen Conjugates as Immunostimulating Agents.
Willems MM, Zom GG, Meeuwenoord N, Khan S, Ossendorp F, Overkleeft HS, van der Marel GA, Filippov DV, Codée JD. Willems MM, et al. Among authors: zom gg. ChemMedChem. 2016 Jan 19;11(2):190-8. doi: 10.1002/cmdc.201500196. Epub 2015 Jun 9. ChemMedChem. 2016. PMID: 26059481
15 results