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Massively parallel base editing screens to map variant effects on anti-tumor hallmarks of primary human T cells.
Walsh ZH, Shah P, Kothapalli N, Nikolenyi G, Shah SB, Leuzzi G, Mu M, Ho P, Abuzaid S, Brodtman ZD, Vasan N, AlQuraishi M, Milner JD, Ciccia A, Melms JC, Izar B. Walsh ZH, et al. Among authors: ciccia a. bioRxiv [Preprint]. 2023 Dec 14:2023.12.13.571465. doi: 10.1101/2023.12.13.571465. bioRxiv. 2023. PMID: 38168306 Free PMC article. Preprint.
CRISPRmap: Sequencing-free optical pooled screens mapping multi-omic phenotypes in cells and tissue.
Gu J, Iyer A, Wesley B, Taglialatela A, Leuzzi G, Hangai S, Decker A, Gu R, Klickstein N, Shuai Y, Jankovic K, Parker-Burns L, Jin Y, Zhang JY, Hong J, Niu S, Chou J, Landau DA, Azizi E, Chan EM, Ciccia A, Gaublomme JT. Gu J, et al. Among authors: ciccia a. bioRxiv [Preprint]. 2023 Dec 26:2023.12.26.572587. doi: 10.1101/2023.12.26.572587. bioRxiv. 2023. PMID: 38234835 Free PMC article. Preprint.
Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA polyubiquitination.
Wang YC, Kelso AA, Karamafrooz A, Chen YH, Chen WK, Cheng CT, Qi Y, Gu L, Malkas L, Kung HJ, Moldovan GL, Ciccia A, Stark JM, Ann DK. Wang YC, et al. Among authors: ciccia a. bioRxiv [Preprint]. 2023 Feb 3:2023.01.31.526362. doi: 10.1101/2023.01.31.526362. bioRxiv. 2023. PMID: 36778247 Free PMC article. Updated. Preprint.
Mechanism of DNA unwinding by hexameric MCM8-9 in complex with HROB.
Acharya A, Bret H, Huang JW, Mütze M, Göse M, Kissling V, Seidel R, Ciccia A, Guérois R, Cejka P. Acharya A, et al. Among authors: ciccia a. bioRxiv [Preprint]. 2023 Jun 12:2023.06.12.544631. doi: 10.1101/2023.06.12.544631. bioRxiv. 2023. PMID: 37398313 Free PMC article. Updated. Preprint.
Extrachromosomal telomere DNA derived from excessive strand displacements.
Lee J, Lee J, Sohn EJ, Taglialatela A, O'Sullivan RJ, Ciccia A, Min J. Lee J, et al. Among authors: ciccia a. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2318438121. doi: 10.1073/pnas.2318438121. Epub 2024 May 2. Proc Natl Acad Sci U S A. 2024. PMID: 38696464
Mechanism of DNA unwinding by MCM8-9 in complex with HROB.
Acharya A, Bret H, Huang JW, Mütze M, Göse M, Kissling VM, Seidel R, Ciccia A, Guérois R, Cejka P. Acharya A, et al. Among authors: ciccia a. Nat Commun. 2024 Apr 27;15(1):3584. doi: 10.1038/s41467-024-47936-8. Nat Commun. 2024. PMID: 38678026 Free PMC article.
85 results