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Anti-Ebola virus mAb 3A6 with unprecedented potency protects highly viremic animals from fatal outcome and physically lifts its glycoprotein target from the virion membrane.
Saphire E, Salie ZL, Ke Z, Halfmann P, DeWald LE, McArdle S, Grinyo A, Davidson E, Schendel S, Hariharan C, Norris M, Yu X, Chennareddy C, Xiong X, Heinrich M, Holbrook M, Doranz B, Crozier I, Hastie K, Kawaoka Y, Branco L, Kuhn J, Briggs J, Worwa G, Davis C, Ahmed R. Saphire E, et al. Among authors: grinyo a. Res Sq [Preprint]. 2023 Dec 22:rs.3.rs-3722563. doi: 10.21203/rs.3.rs-3722563/v1. Res Sq. 2023. PMID: 38196595 Free PMC article. Preprint.
Proteo-Genomic Analysis Identifies Two Major Sites of Vulnerability on Ebolavirus Glycoprotein for Neutralizing Antibodies in Convalescent Human Plasma.
Gilchuk P, Guthals A, Bonissone SR, Shaw JB, Ilinykh PA, Huang K, Bombardi RG, Liang J, Grinyo A, Davidson E, Chen EC, Gunn BM, Alter G, Saphire EO, Doranz BJ, Bukreyev A, Zeitlin L, Castellana N, Crowe JE Jr. Gilchuk P, et al. Among authors: grinyo a. Front Immunol. 2021 Jul 16;12:706757. doi: 10.3389/fimmu.2021.706757. eCollection 2021. Front Immunol. 2021. PMID: 34335620 Free PMC article.
Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques immunized with HCV envelope glycoproteins.
Chen F, Tzarum N, Lin X, Giang E, Velázquez-Moctezuma R, Augestad EH, Nagy K, He L, Hernandez M, Fouch ME, Grinyó A, Chavez D, Doranz BJ, Prentoe J, Stanfield RL, Lanford R, Bukh J, Wilson IA, Zhu J, Law M. Chen F, et al. Among authors: grinyo a. Immunity. 2021 Apr 13;54(4):781-796.e4. doi: 10.1016/j.immuni.2021.02.013. Epub 2021 Mar 5. Immunity. 2021. PMID: 33675683 Free PMC article.