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Anti-Ebola virus mAb 3A6 with unprecedented potency protects highly viremic animals from fatal outcome and physically lifts its glycoprotein target from the virion membrane.
Saphire E, Salie ZL, Ke Z, Halfmann P, DeWald LE, McArdle S, Grinyo A, Davidson E, Schendel S, Hariharan C, Norris M, Yu X, Chennareddy C, Xiong X, Heinrich M, Holbrook M, Doranz B, Crozier I, Hastie K, Kawaoka Y, Branco L, Kuhn J, Briggs J, Worwa G, Davis C, Ahmed R. Saphire E, et al. Among authors: holbrook m. Res Sq [Preprint]. 2023 Dec 22:rs.3.rs-3722563. doi: 10.21203/rs.3.rs-3722563/v1. Res Sq. 2023. PMID: 38196595 Free PMC article. Preprint.
Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses.
Milligan JC, Davis CW, Yu X, Ilinykh PA, Huang K, Halfmann PJ, Cross RW, Borisevich V, Agans KN, Geisbert JB, Chennareddy C, Goff AJ, Piper AE, Hui S, Shaffer KCL, Buck T, Heinrich ML, Branco LM, Crozier I, Holbrook MR, Kuhn JH, Kawaoka Y, Glass PJ, Bukreyev A, Geisbert TW, Worwa G, Ahmed R, Saphire EO. Milligan JC, et al. Among authors: holbrook mr. Cell. 2022 Mar 17;185(6):995-1007.e18. doi: 10.1016/j.cell.2022.02.023. Cell. 2022. PMID: 35303429 Free PMC article.
Persistent intraocular Ebola virus RNA is associated with severe uveitis in a convalescent rhesus monkey.
Worwa G, Cooper TK, Yeh S, Shantha JG, Hischak AMW, Klim SE, Byrum R, Kurtz JR, Anthony SM, Aiosa NM, Ragland D, Lee JH, Claire MS, Davis C, Ahmed R, Holbrook MR, Kuhn JH, Saphire EO, Crozier I. Worwa G, et al. Among authors: holbrook mr. Commun Biol. 2022 Nov 9;5(1):1204. doi: 10.1038/s42003-022-04158-2. Commun Biol. 2022. PMID: 36352100 Free PMC article.
In Vivo Activity of Amodiaquine against Ebola Virus Infection.
DeWald LE, Johnson JC, Gerhardt DM, Torzewski LM, Postnikova E, Honko AN, Janosko K, Huzella L, Dowling WE, Eakin AE, Osborn BL, Gahagen J, Tang L, Green CE, Mirsalis JC, Holbrook MR, Jahrling PB, Dyall J, Hensley LE. DeWald LE, et al. Among authors: holbrook mr. Sci Rep. 2019 Dec 27;9(1):20199. doi: 10.1038/s41598-019-56481-0. Sci Rep. 2019. PMID: 31882748 Free PMC article.
Ebola Virus Disease Features Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome in the Rhesus Macaque Model.
Liu DX, Pahar B, Cooper TK, Perry DL, Xu H, Huzella LM, Adams RD, Hischak AMW, Hart RJ, Bernbaum R, Rivera D, Anthony S, Claire MS, Byrum R, Cooper K, Reeder R, Kurtz J, Hadley K, Wada J, Crozier I, Worwa G, Bennett RS, Warren T, Holbrook MR, Schmaljohn CS, Hensley LE. Liu DX, et al. Among authors: holbrook mr. J Infect Dis. 2023 Aug 16;228(4):371-382. doi: 10.1093/infdis/jiad203. J Infect Dis. 2023. PMID: 37279544
Identification of Combinations of Approved Drugs With Synergistic Activity Against Ebola Virus in Cell Cultures.
Dyall J, Nelson EA, DeWald LE, Guha R, Hart BJ, Zhou H, Postnikova E, Logue J, Vargas WM, Gross R, Michelotti J, Deiuliis N, Bennett RS, Crozier I, Holbrook MR, Morris PJ, Klumpp-Thomas C, McKnight C, Mierzwa T, Shinn P, Glass PJ, Johansen LM, Jahrling PB, Hensley LE, Olinger GG Jr, Thomas C, White JM. Dyall J, et al. Among authors: holbrook mr. J Infect Dis. 2018 Nov 22;218(suppl_5):S672-S678. doi: 10.1093/infdis/jiy304. J Infect Dis. 2018. PMID: 29939303 Free PMC article.
Evaluation of the Activity of Lamivudine and Zidovudine against Ebola Virus.
Cong Y, Dyall J, Hart BJ, DeWald LE, Johnson JC, Postnikova E, Zhou H, Gross R, Rojas O, Alexander I, Josleyn N, Zhang T, Michelotti J, Janosko K, Glass PJ, Flint M, McMullan LK, Spiropoulou CF, Mierzwa T, Guha R, Shinn P, Michael S, Klumpp-Thomas C, McKnight C, Thomas C, Eakin AE, O'Loughlin KG, Green CE, Catz P, Mirsalis JC, Honko AN, Olinger GG Jr, Bennett RS, Holbrook MR, Hensley LE, Jahrling PB. Cong Y, et al. Among authors: holbrook mr. PLoS One. 2016 Nov 30;11(11):e0166318. doi: 10.1371/journal.pone.0166318. eCollection 2016. PLoS One. 2016. PMID: 27902714 Free PMC article.
The Calcium Channel Blocker Bepridil Demonstrates Efficacy in the Murine Model of Marburg Virus Disease.
DeWald LE, Dyall J, Sword JM, Torzewski L, Zhou H, Postnikova E, Kollins E, Alexander I, Gross R, Cong Y, Gerhardt DM, Johnson RF, Olinger GG Jr, Holbrook MR, Hensley LE, Jahrling PB. DeWald LE, et al. Among authors: holbrook mr. J Infect Dis. 2018 Nov 22;218(suppl_5):S588-S591. doi: 10.1093/infdis/jiy332. J Infect Dis. 2018. PMID: 29982632 Free PMC article.
Formulation, Stability, Pharmacokinetic, and Modeling Studies for Tests of Synergistic Combinations of Orally Available Approved Drugs against Ebola Virus In Vivo.
Finch CL, Dyall J, Xu S, Nelson EA, Postnikova E, Liang JY, Zhou H, DeWald LE, Thomas CJ, Wang A, Xu X, Hughes E, Morris PJ, Mirsalis JC, Nguyen LH, Arolfo MP, Koci B, Holbrook MR, Hensley LE, Jahrling PB, Schmaljohn C, Johansen LM, Olinger GG, Schiffer JT, White JM. Finch CL, et al. Among authors: holbrook mr. Microorganisms. 2021 Mar 10;9(3):566. doi: 10.3390/microorganisms9030566. Microorganisms. 2021. PMID: 33801811 Free PMC article.
Testing therapeutics in cell-based assays: Factors that influence the apparent potency of drugs.
Postnikova E, Cong Y, DeWald LE, Dyall J, Yu S, Hart BJ, Zhou H, Gross R, Logue J, Cai Y, Deiuliis N, Michelotti J, Honko AN, Bennett RS, Holbrook MR, Olinger GG, Hensley LE, Jahrling PB. Postnikova E, et al. PLoS One. 2018 Mar 22;13(3):e0194880. doi: 10.1371/journal.pone.0194880. eCollection 2018. PLoS One. 2018. PMID: 29566079 Free PMC article.
372 results