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Kaposi's sarcoma herpesvirus latency-associated nuclear antigen broadly regulates viral gene expression and is essential for lytic infection.
Li S, Wang M, Van Sciver N, Szymula A, Tumuluri VS, George A, Ramachandran A, Raina K, Costa CN, Zhao B, Kazemian M, Simas JP, Kaye KM. Li S, et al. Among authors: simas jp. PLoS Pathog. 2024 Jan 17;20(1):e1011907. doi: 10.1371/journal.ppat.1011907. eCollection 2024 Jan. PLoS Pathog. 2024. PMID: 38232124 Free PMC article.
MLL1 is regulated by KSHV LANA and is important for virus latency.
Tan M, Li S, Juillard F, Chitas R, Custódio TF, Xue H, Szymula A, Sun Q, Liu B, Álvarez ÁL, Chen S, Huang J, Simas JP, McVey CE, Kaye KM. Tan M, et al. Among authors: simas jp. Nucleic Acids Res. 2021 Dec 16;49(22):12895-12911. doi: 10.1093/nar/gkab1094. Nucleic Acids Res. 2021. PMID: 34850113 Free PMC article.
Crystal structure of the gamma-2 herpesvirus LANA DNA binding domain identifies charged surface residues which impact viral latency.
Correia B, Cerqueira SA, Beauchemin C, Pires de Miranda M, Li S, Ponnusamy R, Rodrigues L, Schneider TR, Carrondo MA, Kaye KM, Simas JP, McVey CE. Correia B, et al. Among authors: simas jp. PLoS Pathog. 2013;9(10):e1003673. doi: 10.1371/journal.ppat.1003673. Epub 2013 Oct 17. PLoS Pathog. 2013. PMID: 24146618 Free PMC article.
KSHV LANA acetylation-selective acidic domain reader sequence mediates virus persistence.
Juillard F, de Miranda MP, Li S, Franco A, Seixas AF, Liu B, Álvarez ÁL, Tan M, Szymula A, Kaye KM, Simas JP. Juillard F, et al. Among authors: simas jp. Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22443-22451. doi: 10.1073/pnas.2004809117. Epub 2020 Aug 20. Proc Natl Acad Sci U S A. 2020. PMID: 32820070 Free PMC article.
68 results